E3 ubiquitin-protein ligase TRIM22 (TRIM22) Recombinant Protein | TRIM22 recombinant protein

Recombinant Human E3 ubiquitin-protein ligase TRIM22 (TRIM22)

Cat. Num. AAA1401200

• Gene Names: TRIM22; RNF94; STAF50; GPSTAF50
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: E3 ubiquitin-protein ligase TRIM22 (TRIM22); Recombinant Human E3 ubiquitin-protein ligase TRIM22 (TRIM22); TRIM22 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-498, Full length protein
• Sequence: MDFSVKVDIEKEVTCPICLELLTEPLSLDCGHSFCQACITAKIKESVIISRGESSCPVCQTRFQPGNLRPNRHLANIVERVKEVKMSPQEGQKRDVCEHHGKKLQIFCKEDGKVICWVCELSQEHQGHQTFRINEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRVPDLSGMLQVLKELTDVQYYWVDVMLNPGSATSNVAISVDQRQVKTVRTCTFKNSNPCDFSAFGVFGCQYFSSGKYYWEVDVSGKIAWILGVHSKISSLNKRKSSGFAFDPSVNYSKVYSRYRPQYGYWVIGLQNTCEYNAFEDSSSSDPKVLTLFMAVPPCRIGVFLDYEAGIVSFFNVTNHGALIYKFSGCRFSRPAYPYFNPWNCLVPMTVCPPSS
• Sequence Length: 498

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for TRIM22 recombinant protein

This protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon s antiviral effects.

NCBI and Uniprot Product Information

• NCBI GI #: 313760629
• NCBI GeneID: 10346
• NCBI Accession #: NP_001186502.1
• NCBI GenBank Nucleotide #: NM_001199573.1
• UniProt Accession #: Q8IYM9; Q05CQ0; Q15521
• Molecular Weight: 56,429 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase TRIM22 isoform 2
• NCBI Official Synonym Full Names: tripartite motif containing 22
• NCBI Official Symbol: TRIM22
• NCBI Official Synonym Symbols: RNF94; STAF50; GPSTAF50
• NCBI Protein Information: E3 ubiquitin-protein ligase TRIM22
• UniProt Protein Name: E3 ubiquitin-protein ligase TRIM22
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: TRIM22
• UniProt Synonym Gene Names: RNF94; STAF50

NCBI Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Uniprot Description

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.