Human tripartite motif-containing 22 ELISA Kit | TRIM22 elisa kit
Human E3 ubiquitin-protein ligase TRIM22, TRIM22 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Uniprot Description
TRIM22: Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor; Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.-
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: nucleoplasm; Cajal body; cytoplasm; nuclear speck; nucleus; cytosol
Molecular Function: zinc ion binding; transcription corepressor activity; transcription factor activity; ligase activity
Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to virus; cytokine and chemokine mediated signaling pathway; protein ubiquitination; immune response; positive regulation of transcription factor activity; defense response to virus; activation of NF-kappaB transcription factor
Research Articles on TRIM22
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Product Notes
The Human TRIM22 trim22 (Catalog #AAA9336494) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9336494 ELISA Kit recognizes Human TRIM22. It is sometimes possible for the material contained within the vial of "tripartite motif-containing 22, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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