Three prime repair exonuclease 1 (TREX1) Recombinant Protein | TREX1 recombinant protein

Recombinant Human Three prime repair exonuclease 1 (TREX1)

Cat. Num. AAA1332376

• Gene Names: TREX1; CRV; AGS1; DRN3; HERNS
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Three prime repair exonuclease 1 (TREX1); Recombinant Human Three prime repair exonuclease 1 (TREX1); TREX1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-369aa; Full Length
• Sequence: MGPGARRQGRIVQGRPEMCFCPPPTPLPPLRILTLGTHTPTPCSSPGSAAGTYPTMGSQALPPGPMQTLIFFDMEATGLPFSQPKVTELCLLAVHRCALESPPTSQGPPPTVPPPPRVVDKLSLCVAPGKACSPAASEITGLSTAVLAAHGRQCFDDNLANLLLAFLRRQPQPWCLVAHNGDRYDFPLLQAELAMLGLTSALDGAFCVDSITALKALERASSPSEHGPRKSYSLGSIYTRLYGQSPPDSHTAEGDVLALLSICQWRPQALLRWVDAHARPFGTIRPMYGVTASARTKPRPSAVTTTAHLATTRNTSPSLGESRGTKDLPPVKDPGALSREGLLAPLGLLAILTLAVATLYGLSLATPGE

• Species: Human
• Sequence Note: The sequence corresponds to Uniprot Q9NSU2 version 2017_10/2017_10|25-Oct-2017
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for TREX1 recombinant protein

This gene encodes the major 3 ->5 DNA exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3 ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 404434375
• NCBI GeneID: 11277
• NCBI Accession #: NP_009179.2
• NCBI GenBank Nucleotide #: NM_007248.4
• UniProt Accession #: Q9NSU2; Q8TEU2; Q9BPW1; Q9Y4X2; B2RCN9
• Molecular Weight: 32,276 Da
• NCBI Official Full Name: three-prime repair exonuclease 1 isoform c
• NCBI Official Synonym Full Names: three prime repair exonuclease 1
• NCBI Official Symbol: TREX1
• NCBI Official Synonym Symbols: CRV; AGS1; DRN3; HERNS
• NCBI Protein Information: three-prime repair exonuclease 1
• UniProt Protein Name: Three-prime repair exonuclease 1
• Protein Family: Three-prime repair exonuclease
• UniProt Gene Name: TREX1
• UniProt Synonym Gene Names: DNase III

NCBI Description

This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Uniprot Description

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.