TPBG recombinant protein

Human CellExp TPBG; Human Recombinant

Cat. Num. AAA8400653

• Gene Names: TPBG; 5T4; M6P1; 5T4AG
• Purity: >95% by SDS-PAGE
• Synonyms: TPBG; Human CellExp TPBG; Human Recombinant; Trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; 5T4 oncotrophoblast glycoprotein; M6P1; Wnt-activated inhibitory factor 1; WAIF1; TPBG recombinant protein

• Host: HEK293 cells
• Specificity: Antagonist of the of Wnt/beta-catenin signaling pathway
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Lyophilized powder
• Sequence: Ser32-Ser355

• Source: Human
• Tag: 6xHis tag fused to C-terminus with GS linker
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH7.4). Do not vortex.; Shipping: Gel Pack; Shelf Life: Est.~12 months; Country of Origin: USA

SDS-Page

Related Product Information for TPBG recombinant protein

Trophoblast glycoprotein, also known as TPBG or 5T4, is a human cell surface protein encoded by a TPBG gene and an antagonist of the of Wnt/beta-catenin signaling pathway. TPBG/5T4 is rarely expressed in normal adult tissues, but is present at high levels in placenta and in most common tumors, typically more than 80% of carcinomas of the kidney, breast, colon, prostate, and ovary. Due to its selective expression, it is often used as a prognostic aid in cancer cases. Recently, it has been shown that TPBG inhibits Wnt/beta-catenin signaling, a signaling system central to many developmental and pathological processes and therefore serves as a therapeutic target of several anticancer agents currently in clinical development.

Product Categories/Family for TPBG recombinant protein

Web Categories; Proteins and Enzymes; Proteins and Enzymes (A-Z); Cancer Research; Oncogenic Signaling Pathway; GSK-3-Wnt Signaling; Proteins-Enzymes; Human cell expressed recombinant proteins

NCBI and Uniprot Product Information

• NCBI GI #: 262205665
• NCBI GeneID: 7162
• NCBI Accession #: NP_001159864.1
• NCBI GenBank Nucleotide #: NM_001166392.1
• UniProt Accession #: Q13641
• Molecular Weight: 46,032 Da
• NCBI Official Full Name: trophoblast glycoprotein
• NCBI Official Synonym Full Names: trophoblast glycoprotein
• NCBI Official Symbol: TPBG
• NCBI Official Synonym Symbols: 5T4; M6P1; 5T4AG
• NCBI Protein Information: trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncotrophoblast glycoprotein; 5T4 oncofetal trophoblast glycoprotein
• UniProt Protein Name: Trophoblast glycoprotein
• Protein Family: Trophoblast glycoprotein
• UniProt Gene Name: TPBG
• UniProt Synonym Gene Names: 5T4; 5T4 oncotrophoblast glycoprotein
• UniProt Entry Name: TPBG_HUMAN

NCBI Description

This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]

Uniprot Description

Subcellular location: Membrane; Single-pass type I membrane protein

Potential.

Tissue specificity: Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.

Miscellaneous: Antigen 5T4 is overexpressed by a wide spectrum of cancers, including colorectal, ovarian and gastric, but with a limited normal tissue expression. Could be used for tumor immunotherapy.

Sequence similarities: Contains 6 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.