Tonsoku-like protein (TONSL) Recombinant Protein | TONSL recombinant protein

Recombinant Human Tonsoku-like protein (TONSL) , partial

• Gene Names: TONSL; IKBR; NFKBIL2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tonsoku-like protein (TONSL); Recombinant Human Tonsoku-like protein (TONSL); partial; TONSL recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1378

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for TONSL recombinant protein

This protein is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus.

NCBI and Uniprot Product Information

• NCBI GI #: 187608777
• NCBI GeneID: 4796
• NCBI Accession #: NP_038460.4
• NCBI GenBank Nucleotide #: NM_013432.4
• UniProt Accession #: Q96HA7; Q13006; Q9UGJ2; B5MDP0; C9JKB1; C9JNV8
• Molecular Weight: 150,894 Da
• NCBI Official Full Name: tonsoku-like protein
• NCBI Official Synonym Full Names: tonsoku like, DNA repair protein
• NCBI Official Symbol: TONSL
• NCBI Official Synonym Symbols: IKBR; NFKBIL2
• NCBI Protein Information: tonsoku-like protein
• UniProt Protein Name: Tonsoku-like protein
• UniProt Gene Name: TONSL
• UniProt Synonym Gene Names: IKBR; NFKBIL2; I-kappa-B-related protein; IkappaBR

NCBI Description

The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]

Uniprot Description

Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork-associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold.