Tumor necrosis factor ligand superfamily member 8 (TNFSF8) Recombinant Protein | TNFSF8 recombinant protein

Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8)

• Gene Names: TNFSF8; CD153; CD30L; CD30LG
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tumor necrosis factor ligand superfamily member 8 (TNFSF8); Recombinant Human Tumor necrosis factor ligand superfamily member 8 (TNFSF8); Tumor necrosis factor ligand superfamily member 8; CD30 ligand; CD30-L; CD_antigen=; CD153; TNFSF8 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 63-234
• Sequence: QRTDSIPN SPDNVPLKGG NCSEDLLCIL KRAPFKKSWA YLQVAKHLNK TKLSWNKDGI LHGVRYQDGN LVIQFPGLYF IICQLQFLVQ CPNNSVDLKL ELLINKHIKK QALVTVCESG MQTKHVYQNL SQFLLDYLQV NTTISVNVDT FQYIDTSTFP LENVLSIFLY SNSD
• Sequence Length: 172

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 4507607
• NCBI GeneID: 944
• NCBI Accession #: NP_001235.1
• NCBI GenBank Nucleotide #: NM_001244.3
• UniProt Accession #: P32971; O43404
• Molecular Weight: 26,017 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 8 isoform 1
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 8
• NCBI Official Symbol: TNFSF8
• NCBI Official Synonym Symbols: CD153; CD30L; CD30LG
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 8; CD30-L; CD30 ligand; CD153 antigen; CD30 antigen ligand
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 8
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: TNFSF8
• UniProt Synonym Gene Names: CD30L; CD30LG; CD30-L
• UniProt Entry Name: TNFL8_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

TNFSF8: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Apoptosis; Cytokine

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: extracellular space; integral to plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; defense response to Gram-positive bacterium; CD8-positive, alpha-beta T cell differentiation; cell-cell signaling; apoptosis; positive regulation of transcription from RNA polymerase II promoter; immune response; signal transduction