Tumor necrosis factor ligand superfamily member 12 Recombinant Protein | TNFSF12 recombinant protein
Recombinant Human Tumor necrosis factor ligand superfamily member 12
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Uniprot Description
TNFSF12: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Homotrimer (Potential). Interacts with the angiogenic factor AGGF1/VG5Q. Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain. Belongs to the tumor necrosis factor family.
Protein type: Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Apoptosis
Chromosomal Location of Human Ortholog: 17p13
Cellular Component: extracellular region; extracellular space; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: cytokine activity; protein binding; receptor binding; tumor necrosis factor receptor binding
Biological Process: angiogenesis; apoptosis; cell differentiation; endothelial cell migration; immune response; positive regulation of angiogenesis; positive regulation of endothelial cell proliferation; positive regulation of protein catabolic process; signal transduction; tumor necrosis factor-mediated signaling pathway
Research Articles on TNFSF12
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Product Notes
The TNFSF12 tnfsf12 (Catalog #AAA1136538) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 43-149aa; Extracellular Domain. The amino acid sequence is listed below: SLGSRASLSA QEPAQEELVA EEDQDPSELN PQTEESQDPA PFLNRLVRPR RSAPKGRKTR ARRAIAAHYE VHPRPGQDGA QAGVDGTVSG WEEARINSSS PLRYNRQ. It is sometimes possible for the material contained within the vial of "Tumor necrosis factor ligand superfamily member 12, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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