DcR3 Blocking Peptide | TNFRSF6B blocking peptide

DcR3 Peptide

Cat. Num. AAA152417

• Gene Names: TNFRSF6B; M68; TR6; DCR3; M68E; DJ583P15.1.1
• Applications: Blocking (BL)
• Synonyms: DcR3; DcR3 Peptide; M68; TR6; DCR3; M68E; DJ583P15.1.1; UNQ186/PRO212; Tumor necrosis factor receptor superfamily member 6B; Decoy receptor 3; tumor necrosis factor receptor superfamily; member 6b; decoy; TNFRSF6B blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 1114

• Applicable Applications for TNFRSF6B blocking peptide: Blocking (BL)
• Application Notes: DcR3 peptide is used for blocking the activity of DcR3 antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 16 amino acids near the amino terminus of human DcR3.
• Preparation and Storage: Store DcR3 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 4106877
• NCBI GeneID: 8771
• UniProt Accession #: O95407
• Molecular Weight: 32,680 Da
• NCBI Official Full Name: Homo sapiens decoy receptor 3 (DcR3) mRNA, complete cds
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 6b, decoy
• NCBI Official Symbol: TNFRSF6B
• NCBI Official Synonym Symbols: M68; TR6; DCR3; M68E; DJ583P15.1.1
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 6B
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF6B
• UniProt Synonym Gene Names: DCR3; TR6; DcR3
• UniProt Entry Name: TNF6B_HUMAN

NCBI Description

This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]

Uniprot Description

TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function: protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis