TNFRSF12A recombinant protein

Recombinant Human TNFRSF12A Protein

Cat. Num. AAA8249900

• Gene Names: TNFRSF12A; FN14; CD266; TWEAKR
• Reactivity: Human
• Applications: ELISA, Western Blot, SDS-Page
• Purity: Greater than 95% as determined by reducing SDS-PAGE.
• Synonyms: TNFRSF12A; Recombinant Human TNFRSF12A Protein; FN14; Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor; TweakR; CD antigen CD266; TNFRSF12A recombinant protein

• Host: Human cells
• Reactivity: Human
• Purity/Purification: Greater than 95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 muM filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence: EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWVDDIEGRM DEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
• Sequence Length: 129

• Applicable Applications for TNFRSF12A recombinant protein: ELISA (EIA),Western Blot (WB), SDS-PAGE, Mass Spectrometry (MS)
• Endotoxin: Less than 0.1 ng/mug (1 IEU/mug) as determined by LAL test.
• Directions for Use: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 mug/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Preparation and Storage: Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

Related Product Information for TNFRSF12A recombinant protein

Recombinant Human TNFRSF12A Protein is produced by our mammalian expression system and the target gene encoding Glu28-Trp79 is expressed with a Fc tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 7706186
• NCBI GeneID: 51330
• NCBI Accession #: NP_057723.1
• NCBI GenBank Nucleotide #: NM_016639.2
• UniProt Accession #: Q9NP84; Q9HCS0; D3DUA6
• Molecular Weight: 10,191 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 12A
• NCBI Official Synonym Full Names: TNF receptor superfamily member 12A
• NCBI Official Symbol: TNFRSF12A
• NCBI Official Synonym Symbols: FN14; CD266; TWEAKR
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 12A
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 12A
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF12A
• UniProt Synonym Gene Names: FN14; FGF-inducible 14; TweakR
• UniProt Entry Name: TNR12_HUMAN

Uniprot Description

TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: plasma membrane

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; tumor necrosis factor-mediated signaling pathway