Tumor Necrosis Factor Receptor Superfamily, Member 10B (TNFRSF10B) Recombinant Protein | TNFRSF10B recombinant protein

Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 10B (TNFRSF10B)

Cat. Num. AAA2012428

• Gene Names: Tnfrsf10b; MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: Tumor Necrosis Factor Receptor Superfamily; Member 10B (TNFRSF10B); Recombinant Tumor Necrosis Factor Receptor Superfamily; TNFRSF10B recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
• Sequence: The target protein is fused with N-terminal His-Tag, its sequence is listed below.; MGHHHHHHSGSEF-PAHNRPA GLQRPEESPS RGPCLAGQYL SEGNCKPCRE GIDYTSHSNH SLDSCILCTV CKEDKVVETR CNITTNTVCR CKPGTFEDKD SPEICQSCSN CTDGEEELTS CTPRENRKCV SKTAWASWHK
• Sequence Length: 381

• Applicable Applications for TNFRSF10B recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Organism: Mus musculus (Mouse)
• Expression System: Prokaryotic expression
• Residues: Pro54~Lys180 (Accession # Q9QZM4) with N-terminal His-Tag
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 31981095
• NCBI GeneID: 21933
• NCBI Accession #: NP_064671.2
• NCBI GenBank Nucleotide #: NM_020275.4
• UniProt Accession #: Q9QZM4; Q6GSD9; Q9JJL5; Q9JJL6
• Molecular Weight: 15.6kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 10B
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 10b
• NCBI Official Symbol: Tnfrsf10b
• NCBI Official Synonym Symbols: MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 10B; death receptor 5; KILLER/DR5 TRAIL death-inducing receptor
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 10B
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: Tnfrsf10b
• UniProt Synonym Gene Names: Dr5; Killer
• UniProt Entry Name: TR10B_MOUSE

Uniprot Description

TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane

Molecular Function: protease binding; TRAIL binding; caspase activator activity; transcription factor binding

Biological Process: caspase activation; regulation of apoptosis; induction of apoptosis via death domain receptors; apoptosis; signal transduction