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SDS-PAGE

TRAIL R2 / CD262 / TNFRSF10B recombinant protein

Recombinant Mouse TRAIL R2 / CD262 / TNFRSF10B Protein (His tag)

Gene Names
Tnfrsf10b; MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
Purity
> 95 % as determined by SDS-PAGE
Synonyms
TRAIL R2 / CD262 / TNFRSF10B; Recombinant Mouse TRAIL R2 / CD262 / TNFRSF10B Protein (His tag); Tnfrsf10b; mDR5; KILLER; Ly98; MK; TRAILR2; TRICK2A; TRICK2B; TRICKB; TRAIL R2 / CD262 / TNFRSF10B recombinant protein
Ordering
For Research Use Only!
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
381
Application Notes
The secreted recombinant mouse TNFRSF10B consists of 136 amino acids and has a calculated molecular mass of 15 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 25-35 kDa in SDS-PAGE under reducing conditions.
Predicted N Terminal
Asn 53
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

SDS-PAGE
Related Product Information for TRAIL R2 / CD262 / TNFRSF10B recombinant protein
Background: Tumor necrosis factor receptor superfamily, member 10b, official symbol TNFRSF10B, also known as Death receptor 5, CD262, TNF-related apoptosis-inducing ligand receptor 2 (TRAIL R2), is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. TRAIL R2/CD262/TNFRSF10B was purified independently as the only receptor for TRAIL detectable on the surface of two different human cell lines that undergo apoptosis upon stimulation with TRAIL. TRAIL R2/CD262/TNFRSF10B contains two extracellular cysteine-rich repeats, typical for TNF receptor (TNFR) family members, and a cytoplasmic death domain. TRAIL R2/CD262/TNFRSF10B mediates apoptosis via the intracellular adaptor molecule FADD/MORT1. TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family. Defects in TRAIL R2/CD262/TNFRSF10B may be a cause of head and neck squamous cell carcinomas (HNSCC) also known as squamous cell carcinoma of the head and neck.

Description: A DNA sequence encoding the extracellular domain of mouse TNFRSF10B (NP_064671.2) (Met 1-Ser 177) was expressed, with a C-terminal polyhistidine tag.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
42,165 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 10B
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 10b
NCBI Official Symbol
Tnfrsf10b
NCBI Official Synonym Symbols
MK; DR5; Ly98; KILLER; TRICKB; TRAILR2; TRICK2A; TRICK2B
NCBI Protein Information
tumor necrosis factor receptor superfamily member 10B
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 10B
UniProt Gene Name
Tnfrsf10b
UniProt Synonym Gene Names
Dr5; Killer

Uniprot Description

TRAIL-R1: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14|14 D2

Cellular Component: cell surface; integral to plasma membrane; membrane

Molecular Function: caspase activator activity; protease binding; TRAIL binding; transcription factor binding; tumor necrosis factor receptor activity

Biological Process: apoptosis; immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; regulation of apoptosis; regulation of cell proliferation; response to lipopolysaccharide

Research Articles on TRAIL R2 / CD262 / TNFRSF10B

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Product Notes

The TRAIL R2 / CD262 / TNFRSF10B tnfrsf10b (Catalog #AAA2546994) is a Recombinant Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The secreted recombinant mouse TNFRSF10B consists of 136 amino acids and has a calculated molecular mass of 15 kDa. As a result of glycosylation, the apparent molecular mass of the recombinant protein is approximately 25-35 kDa in SDS-PAGE under reducing conditions. Researchers should empirically determine the suitability of the TRAIL R2 / CD262 / TNFRSF10B tnfrsf10b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRAIL R2 / CD262 / TNFRSF10B, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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