TMPRSS2 recombinant protein

Recombinant Human TMPRSS2 protein

Cat. Num. AAA1560466

• Gene Names: TMPRSS2; PP9284; PRSS10
• Applications: Immunogen
• Purity: >90% as determined by SDS-PAGE
• Synonyms: TMPRSS2; Recombinant Human TMPRSS2 protein; Transmembrane protease serine 2; Serine protease 10.; TMPRSS2 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Supplied as solution form in PBS, pH7.5 or lyophilized from PBS, pH7.5

• Applicable Applications for TMPRSS2 recombinant protein: Immunogen
• Species: Human
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -99 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.

SDS-Page

Related Product Information for TMPRSS2 recombinant protein

Recombinant Human TMPRSS2 is produced by E Coli expression system and the target gene encoding Ser284-Gly492 is expressed with His Tag
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate. Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells. In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia.

Product Categories/Family for TMPRSS2 recombinant protein

2019-ncov related protein; Other proteins

NCBI and Uniprot Product Information

• NCBI GI #: 227499990
• NCBI GeneID: 7113
• NCBI Accession #: NP_001128571.1
• NCBI GenBank Nucleotide #: NM_001135099.1
• UniProt Accession #: O15393; Q6GTK7; Q9BXX1; A8K6Z8; B2R8E5; B7Z459; D3DSJ2; F8WES1
• Molecular Weight: 57,690 Da
• NCBI Official Full Name: transmembrane protease serine 2 isoform 1
• NCBI Official Synonym Full Names: transmembrane serine protease 2
• NCBI Official Symbol: TMPRSS2
• NCBI Official Synonym Symbols: PP9284; PRSS10
• NCBI Protein Information: transmembrane protease serine 2
• UniProt Protein Name: Transmembrane protease serine 2
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: TMPRSS2
• UniProt Synonym Gene Names: PRSS10

NCBI Description

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Uniprot Description

Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus (SARS-CoV) infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.