Transmembrane protease serine 11D (TMPRSS11D) Recombinant Protein | TMPRSS11D recombinant protein

Recombinant Human Transmembrane protease serine 11D (TMPRSS11D), partial

Cat. Num. AAA7057927

• Gene Names: TMPRSS11D; HAT
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Transmembrane protease serine 11D (TMPRSS11D); Recombinant Human Transmembrane protease serine 11D (TMPRSS11D); partial; TMPRSS11D recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 42-418. Partial
• Sequence: AFDQKSYFYRSSFQLLNVEYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPSTEITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 4758508
• NCBI GeneID: 9407
• NCBI Accession #: NP_004253.1
• NCBI GenBank Nucleotide #: NM_004262.2
• UniProt Accession #: O60235; Q08AF6
• Molecular Weight: 46,263 Da
• NCBI Official Full Name: transmembrane protease serine 11D
• NCBI Official Synonym Full Names: transmembrane serine protease 11D
• NCBI Official Symbol: TMPRSS11D
• NCBI Official Synonym Symbols: HAT
• NCBI Protein Information: transmembrane protease serine 11D
• UniProt Protein Name: Transmembrane protease serine 11D
• Protein Family: Transmembrane protease serine
• UniProt Gene Name: TMPRSS11D
• UniProt Synonym Gene Names: HAT

NCBI Description

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

Uniprot Description

May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate.