TM173 Blocking Peptide | TMEM173 blocking peptide

TM173 Antibody (C-term) Blocking Peptide

• Gene Names: TMEM173; ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING
• Synonyms: TM173; TM173 Antibody (C-term) Blocking Peptide; Stimulator of interferon genes protein; hSTING; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173; TMEM173; MITA; STING; TMEM173 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 379

• Cellular Location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Cytoplasm Note: In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited
• Tissue Location: Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TMEM173 blocking peptide

Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection.

NCBI and Uniprot Product Information

• NCBI GI #: 74727720
• NCBI GeneID: 340061
• UniProt Accession #: Q86WV6; A8K3P6; B6EB35; D6RBX0; D6RE01; D6RID9
• Molecular Weight: 42,193 Da
• NCBI Official Full Name: Stimulator of interferon genes protein
• NCBI Official Synonym Full Names: transmembrane protein 173
• NCBI Official Symbol: TMEM173
• NCBI Official Synonym Symbols: ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING
• NCBI Protein Information: stimulator of interferon genes protein
• UniProt Protein Name: Stimulator of interferon genes protein
• Protein Family: Stimulator of interferon genes protein
• UniProt Gene Name: TMEM173
• UniProt Synonym Gene Names: ERIS; MITA; STING; hSTING; ERIS; hMITA
• UniProt Entry Name: STING_HUMAN

NCBI Description

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Uniprot Description

TMEM173: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family.

Protein type: Apoptosis; Membrane protein, integral; Mitochondrial; Membrane protein, multi-pass; Endoplasmic reticulum

Chromosomal Location of Human Ortholog: 5q31.2

Cellular Component: cytoplasmic vesicle membrane; endoplasmic reticulum membrane; mitochondrial outer membrane; perinuclear region of cytoplasm

Molecular Function: identical protein binding; protein binding; protein homodimerization activity; protein kinase binding; transcription factor binding

Biological Process: activation of innate immune response; defense response to virus; innate immune response; interferon-beta production; positive regulation of defense response to virus by host; positive regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; regulation of interferon type I production

Disease: Sting-associated Vasculopathy, Infantile-onset