SDS-Page
(Recombinant TMEM173 (STING) (149-379) gel 12.5% SDS-PAGE Coomassie staining M.W.: 27.3 kDa Purity: ? 65% )
TMEM173 recombinant protein
Recombinant TMEM173 (STING)(149-379) protein
Gene Names
TMEM173; ERIS; MITA; MPYS; NET23; STING
Synonyms
TMEM173; Recombinant TMEM173 (STING)(149-379) protein; Transmembrane Protein 173; Endoplasmic Reticulum Interferon Stimulator; HMITA; NET23; ERIS; MPYS; MITA; SAVI; TMEM173 recombinant protein
Host
E Coli
Form/Format
Recombinant TMEM173 (STING)(149-379) protein is supplied in 25mM Tris pH8.0, 300mM NaCl, 10% glycerol.
Protein Species
Human
Tag
His-Tag
Notes
This product was manufactured as described in Protein Details. Where possible, We has developed functional or activity assays for recombinant proteins. All available data for a given product is shown on the lot-specific Technical Data Sheet.
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Recombinant proteins in solution are temperature sensitive and must be stored at -80 degree C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Shipping Temp: Dry Ice
Shipping Temp: Dry Ice
SDS-Page
(Recombinant TMEM173 (STING) (149-379) gel 12.5% SDS-PAGE Coomassie staining M.W.: 27.3 kDa Purity: ? 65% )
SDS-Page
(Recombinant TMEM173 (STING) (149-379) gel 12.5% SDS-PAGE Coomassie staining M.W.: 27.3 kDa Purity: ? 65% )
Related Product Information for TMEM173 recombinant protein
Short Description: Recombinant TMEM173 (STING)(149-379) corresponding to amino acids 149-379 of human STING (accession number NP_938023.1) was expressed in E Coli and contains a C-terminal 6xHis-tag with a molecular weight of 27.3 kDa.
Background: STING (Stimulator Of Interferon Genes, also known as TMEM173, HMITA, NET23, ERIS, MPYS, MITA, SAVI) is a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. STING is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. It has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. It acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state.
Background: STING (Stimulator Of Interferon Genes, also known as TMEM173, HMITA, NET23, ERIS, MPYS, MITA, SAVI) is a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. STING is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. It has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. It acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state.
Product Categories/Family for TMEM173 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
379
NCBI Official Full Name
stimulator of interferon genes protein
NCBI Official Synonym Full Names
transmembrane protein 173
NCBI Official Symbol
TMEM173
NCBI Official Synonym Symbols
ERIS; MITA; MPYS; NET23; STING
NCBI Protein Information
stimulator of interferon genes protein; hMITA; hSTING; mediator of IRF3 activation; endoplasmic reticulum IFN stimulator; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stimulator; N-terminal methionine-proline-tyrosine-serine
UniProt Protein Name
Stimulator of interferon genes protein
Protein Family
UniProt Gene Name
TMEM173
UniProt Synonym Gene Names
ERIS; MITA; STING; hSTING; ERIS; hMITA
UniProt Entry Name
STING_HUMAN
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Product Notes
The TMEM173 tmem173 (Catalog #AAA389237) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "TMEM173, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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