Human transmembrane protein 106B ELISA Kit | TMEM106B elisa kit
Human Transmembrane protein 106B, TMEM106B ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TMEM106B: TMEM106B genotype, when containing 3 particular single-nucleotide polymorphisms, is strongly correlated with frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia and 20% of patients with this neurodegenerative disease have autosomal dominant GRN mutations. Expression of TMEM106B associated with these polymorphisms is increased in frontal cortex of patients with FTLD-TDP compared to unaffected controls. Thus, increased TMEM106B expression in the brain may be linked to mechanisms of disease in FTLD-TDP and risk alleles confer genetic susceptibility by increasing gene expression. Belongs to the TMEM106 family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p21.3
Cellular Component: intracellular membrane-bound organelle; lysosomal membrane; late endosome membrane; integral to membrane
Molecular Function: protein binding
Biological Process: lysosome localization; transport; dendrite morphogenesis
Research Articles on TMEM106B
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Product Notes
The Human TMEM106B tmem106b (Catalog #AAA9324230) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9324230 ELISA Kit recognizes Human TMEM106B. It is sometimes possible for the material contained within the vial of "transmembrane protein 106B, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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