Tomoregulin-1 Recombinant Protein | TMEFF1 recombinant protein

Tomoregulin-1 Protein, Human, Recombinant (ECD, hFc Tag)

Cat. Num. AAA8120623

• Gene Names: TMEFF1; TR-1; H7365; C9orf2; CT120.1
• Purity: >85% as determined by SDS-PAGE
• Synonyms: Tomoregulin-1; Tomoregulin-1 Protein; Human; Recombinant (ECD; hFc Tag); Human TMEFF1/Tomoregulin-1 Protein (Fc Tag; ECD); C9orf2 Protein; CT120.1 Protein; H7365 Protein; TR-1 Protein; transmembrane protein with EGF-like and two follistatin-like domains 1; TMEFF1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >85% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Val330

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Ser 40
• Tag: C-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human TMEFF1 (NP_003683.2)(Met1-Val330) was expressed with the Fc region of human IgG1 at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for TMEFF1 recombinant protein

Background: TMEFF1 is a novel transmembrane protein, containing two follisatin domains and an epidermal growth factor-like region. The ectopic expression of TMEFF1 in brain cancer cells resulted in their growth inhibition. That TMEFF1 may behave as a tumor suppressor gene in brain cancers. TMEFF1 and TMEFF2 are putative transmembrane proteins comprised of one epidermal growth factor (EGF)-like domain and two follistatin-like domains. Both TMEFF1 and TMEFF2 are predominantly expressed in the brain.

NCBI and Uniprot Product Information

• NCBI GI #: 29568105
• NCBI GeneID: 8577
• NCBI Accession #: NP_003683.2
• NCBI GenBank Nucleotide #: NM_003692.4
• UniProt Accession #: Q8IYR6; Q13086; Q8N3T8
• Molecular Weight: 37,757 Da
• NCBI Official Full Name: tomoregulin-1
• NCBI Official Synonym Full Names: transmembrane protein with EGF like and two follistatin like domains 1
• NCBI Official Symbol: TMEFF1
• NCBI Official Synonym Symbols: TR-1; H7365; C9orf2; CT120.1
• NCBI Protein Information: tomoregulin-1
• UniProt Protein Name: Tomoregulin-1
• Protein Family: Tomoregulin
• UniProt Gene Name: TMEFF1
• UniProt Synonym Gene Names: C9orf2; TR-1
• UniProt Entry Name: TEFF1_HUMAN

Uniprot Description

TMEFF1: a single-pass type I membrane protein. May inhibit NODAL and BMP signaling during neural patterning. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues. Expressed in a variety of cancers cell lines and in myeloma cells. Belongs to the tomoregulin family. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from RefSeq and UniProtKB

Protein type: Cancer Testis Antigen (CTA); Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q31

Cellular Component: plasma membrane; integral to membrane

Biological Process: multicellular organismal development