TLR8 recombinant protein

Recombinant Human TLR8 protein

Cat. Num. AAA1561340

• Gene Names: TLR8; CD288
• Purity: >90% as determined by SDS-PAGE
• Synonyms: TLR8; Recombinant Human TLR8 protein; TLR8 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human TLR8 (Glu27-Ile140) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for TLR8 recombinant protein

TLR8 polymorphism was associated with protective immunity elicited by vaccination with bacillus Calmette-Guerin (BCG) in a human cohort. That TLR8 as an important driver of TFH cell differentiation and a promising target for TFH cell-skewing vaccine adjuvants. Toll-like receptor (TLR)7/8 plays a crucial role in host recognition/response to viruses and its mucosal expression directly correlates with intestinal inflammation. Toll-like receptor 8 (TLR8) is an important component of the human innate immune system that recognizes single stranded RNA (ssRNA).

Product Categories/Family for TLR8 recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 20302168
• NCBI GeneID: 51311
• NCBI Accession #: NP_619542.1
• NCBI GenBank Nucleotide #: NM_138636.4
• UniProt Accession #: Q9NR97; Q495P4; Q6UXL6; Q9NYG9; B3Y654
• Molecular Weight: 119,828 Da
• NCBI Official Full Name: toll-like receptor 8
• NCBI Official Synonym Full Names: toll-like receptor 8
• NCBI Official Symbol: TLR8
• NCBI Official Synonym Symbols: CD288
• NCBI Protein Information: toll-like receptor 8
• UniProt Protein Name: Toll-like receptor 8
• Protein Family: Toll-like receptor
• UniProt Gene Name: TLR8
• UniProt Entry Name: TLR8_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]

Uniprot Description

TLR8: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22

Cellular Component: Golgi membrane; endoplasmic reticulum membrane; integral to membrane; endosome membrane

Molecular Function: single-stranded RNA binding; DNA binding; RNA binding; double-stranded RNA binding; drug binding; receptor activity

Biological Process: I-kappaB kinase/NF-kappaB cascade; regulation of cytokine secretion; response to virus; positive regulation of interleukin-8 biosynthetic process; microglial cell activation; positive regulation of interferon-alpha biosynthetic process; toll-like receptor 8 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; positive regulation of innate immune response; positive regulation of interferon-beta biosynthetic process; toll-like receptor signaling pathway; innate immune response; toll-like receptor 9 signaling pathway; immunoglobulin mediated immune response; inflammatory response; defense response to virus; positive regulation of interferon-gamma biosynthetic process