Human transducin-like enhancer of split 4 (E (sp1) homolog, Drosophila) ELISA Kit | TLE4 elisa kit
Human Transducin-like enhancer protein 4, TLE4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TLE4: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. In all tissues examined, mostly in brain, and muscle. Belongs to the WD repeat Groucho/TLE family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 9q21.31
Cellular Component: nucleoplasm; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; chromatin binding; transcription corepressor activity
Biological Process: transcription from RNA polymerase II promoter; Notch signaling pathway; Wnt receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter
Research Articles on TLE4
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Product Notes
The Human TLE4 tle4 (Catalog #AAA9333865) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333865 ELISA Kit recognizes Human TLE4. It is sometimes possible for the material contained within the vial of "transducin-like enhancer of split 4 (E (sp1) homolog, Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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