Mouse transducin-like enhancer of split 1 (E (sp1) homolog, Drosophila) ELISA Kit | TLE1 elisa kit
Mouse Transducin-like enhancer protein 1, TLE1 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TLE1: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. Homooligomer and heterooligomer with other family members. Binds LEF1, RUNX1, RUNX3, FOXA2, KDM6A, UTY, histone H3, HESX1, ESRRG and the NF-kappa-B subunit RELA. Interacts with HES1 (via WRPW motif). In all tissues examined, mostly in brain, liver and muscle. Belongs to the WD repeat Groucho/TLE family.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Cellular Component: transcription factor complex; cytoplasm; nucleolus; cytosol; nucleus
Molecular Function: identical protein binding; protein binding; chromatin binding; transcription corepressor activity; transcription factor binding
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway; regulation of transcription, DNA-dependent; transcription, DNA-dependent; negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent
Research Articles on TLE1
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Product Notes
The Mouse TLE1 tle1 (Catalog #AAA9329665) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9329665 ELISA Kit recognizes Mouse TLE1. It is sometimes possible for the material contained within the vial of "transducin-like enhancer of split 1 (E (sp1) homolog, Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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