Tissue Inhibitor of Metalloprotease 1 Recombinant Protein | TIMP1 recombinant protein
Recombinant Human Tissue Inhibitor of Metalloprotease 1, sf9
Gene Names
TIMP1; EPA; EPO; HCI; CLGI; TIMP; TIMP-1
Purity
Greater than 90.0% as determined by SDS-PAGE.
Synonyms
Tissue Inhibitor of Metalloprotease 1; Recombinant Human Tissue Inhibitor of Metalloprotease 1; sf9; TIMP1 Human; Sf9; Tissue Inhibitor of Metalloprotease 1 Human Recombinant; TIMP Metallopeptidase Inhibitor 1; TIMP; EPA; Tissue Inhibitor Of Metalloproteinases 1; Fibroblast Collagenase Inhibitor; Erythroid-Potentiating Activity; Collagenase Inhibitor; TIMP-1; CLGI; Tissue Inhibitor Of Metalloproteinase 1 (Erythroid Potentiating Activity; Collagenase Inhibitor); Erythroid Potentiating Activity; Metalloproteinase Inhibitor 1; EPO; HCI; Metalloproteinase inhibitor 1; TIMP1 recombinant protein
Host
Sf9 Baculovirus Cells
Purity/Purification
Greater than 90.0% as determined by SDS-PAGE.
Form/Format
TIMP1 protein solution (0.2mg/ml) contains phosphate buffered saline (pH7.4).
Sterile Filtered clear solution.
Sterile Filtered clear solution.
Sequence Length
207
Preparation and Storage
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.
Related Product Information for TIMP1 recombinant protein
Introduction: TIMP1 is a member of the TIMP family. TIMP1 is an inducible glycoprotein produced by various cell types. The TIMP1 glycoprotein is a natural inhibitor of the matrix metalloproteinases, which a group of peptidases involved in degradation of the extracellular matrix. TIMP1 binds in a reversible mode to MMPs, with regions in the N-terminal domain binding to the MMP substrate-binding site. On top of its inhibitory function against most of the known MMPs, TIMP1 is able to promote cell proliferation in a broad range of cell types, and may also have an anti-apoptotic role. Furthermore, TIMP1 has erthyroid-potentiating activity via translocation to the nucleus and also inhibits apoptosis in B-cells. The TIMP1 gene is situated within intron 6 of the synapsin I gene and is transcribed in the opposite direction. TIMP1 activity is dependent on the existence of disulfide bonds. TIMP1 transcription is extremely inducible in reaction to many cytokines and hormones.Increased TIMP1 levels are connected with squamous cell laryngeal carcinoma. TIMP1 overexpression is linked to gastric cancer.
Description: TIMP1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 190 amino acids (24-207a.a.) and having a molecular mass of 21.5kDa. (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). TIMP1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Description: TIMP1 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 190 amino acids (24-207a.a.) and having a molecular mass of 21.5kDa. (Molecular size on SDS-PAGE will appear at approximately 18-28kDa). TIMP1 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
Product Categories/Family for TIMP1 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
23,171 Da
NCBI Official Full Name
metalloproteinase inhibitor 1
NCBI Official Synonym Full Names
TIMP metallopeptidase inhibitor 1
NCBI Official Symbol
TIMP1
NCBI Official Synonym Symbols
EPA; EPO; HCI; CLGI; TIMP; TIMP-1
NCBI Protein Information
metalloproteinase inhibitor 1
UniProt Protein Name
Metalloproteinase inhibitor 1
Protein Family
UniProt Gene Name
TIMP1
UniProt Synonym Gene Names
CLGI; TIMP; EPA; Collagenase inhibitor; TIMP-1
UniProt Entry Name
TIMP1_HUMAN
Uniprot Description
TIMP1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Belongs to the protease inhibitor I35 (TIMP) family.
Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: Xp11.3-p11.23
Cellular Component: extracellular region; extracellular space; proteinaceous extracellular matrix
Molecular Function: cytokine activity; metalloendopeptidase inhibitor activity; protease binding; protein binding
Biological Process: extracellular matrix disassembly; negative regulation of catalytic activity; negative regulation of membrane protein ectodomain proteolysis; platelet degranulation; positive regulation of cell proliferation; response to cytokine stimulus; response to hormone stimulus
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Product Notes
The TIMP1 timp1 (Catalog #AAA141136) is a Recombinant Protein produced from Sf9 Baculovirus Cells and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Tissue Inhibitor of Metalloprotease 1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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