THO complex subunit 2 (THO2) Recombinant Protein | THO2 recombinant protein

Recombinant Saccharomyces cerevisiae THO complex subunit 2 (THO2) , partial

Gene Names

THO2; LDB5; RLR1; ZRG13

Purity

Greater or equal to 85% purity as determined by SDS-PAGE.

Synonyms

THO complex subunit 2 (THO2); Recombinant Saccharomyces cerevisiae THO complex subunit 2 (THO2); partial; THO2 recombinant protein

Ordering

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE.

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Sequence Length

1,597

Species

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

NCBI GI #

398364667

NCBI GeneID

855583

NCBI Accession #

NP_014260.3

NCBI GenBank Nucleotide #

NM_001182977.3

UniProt Accession #

P53552; D6W142

Molecular Weight

183,931 Da

NCBI Official Full Name

Tho2p

NCBI Official Symbol

THO2

NCBI Official Synonym Symbols

LDB5; RLR1; ZRG13

NCBI Protein Information

Tho2p

UniProt Protein Name

THO complex subunit 2

Protein Family

THO complex

UniProt Gene Name

THO2

UniProt Synonym Gene Names

LDB5; RLR1; ZRG13

Uniprot Description

Component the THO subcomplex of the TREX complex, which operates in coupling transcription elongation to mRNA export. The THO complex is recruited to transcribed genes and moves along the gene with the elongating polymerase during transcription. THO is important for stabilizing nascent RNA in the RNA polymerase II elongation complex by preventing formation of DNA:RNA hybrids behind the elongating polymerase. It functions in cotranscriptional formation of an export-competent messenger ribonucleoprotein particle (mRNP) by facilitating the loading of ATP-dependent RNA helicase SUB2 and the mRNA export factor YRA1 along the nascent mRNA.

Research Articles on THO2

1. Both THO and Yra1-C stimulated Sub2's intrinsic ATPase activity. The authors propose that THO surveys common landmarks in each nuclear mRNP to localize Sub2 for targeted loading of Yra1.

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Product Notes

The THO2 tho2 (Catalog #AAA1030867) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "THO complex subunit 2 (THO2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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