Human TGFbeta-R3 ELISA Kit | TGFBR3 elisa kit
TGFbeta-R3 (Human) OmniKine ELISA Kit
Human: LAP, Latent TGF-beta1, TGFbeta-R1, TGFbeta-R2, TGFbeta-R2/Fc Chimera, TGFbeta-R2b/Fc Chimera, TGF-beta1, TGF-beta1.2, TGF-beta2, TGF-beta3
Murine: TGFbeta-R3
NCBI and Uniprot Product Information
NCBI Description
This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]
Uniprot Description
TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p22.1
Cellular Component: cell surface; cytoplasm; external side of plasma membrane; extracellular exosome; extracellular space; inhibin-betaglycan-ActRII complex; integral component of plasma membrane; proteinaceous extracellular matrix; receptor complex
Molecular Function: activin binding; coreceptor activity; fibroblast growth factor binding; glycosaminoglycan binding; heparin binding; PDZ domain binding; protein binding; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor binding; transforming growth factor beta-activated receptor activity; type II transforming growth factor beta receptor binding
Biological Process: BMP signaling pathway; cardiac muscle cell proliferation; cell migration; epithelial to mesenchymal transition; heart morphogenesis; immune response; liver development; muscular septum morphogenesis; negative regulation of cell motility; negative regulation of epithelial cell proliferation; negative regulation of transforming growth factor beta receptor signaling pathway; organ regeneration; outflow tract morphogenesis; palate development; positive regulation of cardiac muscle cell proliferation; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of ERK1 and ERK2 cascade; regulation of JNK cascade; regulation of protein binding; response to follicle-stimulating hormone stimulus; response to hypoxia; response to luteinizing hormone; response to prostaglandin E; transforming growth factor beta receptor complex assembly; transforming growth factor beta receptor signaling pathway; ventricular cardiac muscle tissue morphogenesis; ventricular compact myocardium morphogenesis
Research Articles on TGFBR3
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Product Notes
The Human TGFBR3 tgfbr3 (Catalog #AAA9501992) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9501992 ELISA Kit recognizes Human TGFBR3. It is sometimes possible for the material contained within the vial of "TGFbeta-R3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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