Transferrin Receptor Soluble (sTfR) Recombinant Protein | sTfR recombinant protein

Transferrin Receptor Soluble (sTfR)

Cat. Num. AAA313437

• Gene Names: TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
• Applications: ELISA
• Purity: >= 95% pure (SDS-PAGE). Immunoaffinity Chromatography
• Synonyms: Transferrin Receptor Soluble (sTfR); Soluble Transferrin Receptor Recombinant; Soluble Transferrin Receptor; sTfR recombinant protein

• Host: HEK-293 Cell Line
• Purity/Purification: >= 95% pure (SDS-PAGE). Immunoaffinity Chromatography
• Form/Format: Lyophilized
• Sequence Length: 760

• Applicable Applications for sTfR recombinant protein: ELISA (EIA), Immunogen (IM)
• Tag Note: Product does not contain any tags.
• Buffer: 10 mM Tris-HCl, 0.15 M Sodium Chloride, pH 8.0, 5% D-Mannitol, 0.1% CHAPS.
• Reconstitution: Prepare with deionized water to the initial concentration. If further dilution of the product is needed then use the buffer stated below. If diluting to less than 0.1 mg/mL, do not freeze the product.
• Preparation and Storage: Store at -20 degree C. After reconstitution, aliquot and freeze at -70 degree C to avoid repeated freeze-thaw cycles.

Product Categories/Family for sTfR recombinant protein

Pur Cancer

NCBI and Uniprot Product Information

• NCBI GI #: 339516
• NCBI GeneID: 7037
• Molecular Weight: 73.8 kDa
• NCBI Official Full Name: transferrin receptor
• NCBI Official Synonym Full Names: transferrin receptor
• NCBI Official Symbol: TFRC
• NCBI Official Synonym Symbols: T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
• NCBI Protein Information: transferrin receptor protein 1
• UniProt Protein Name: Transferrin receptor protein 1
• Protein Family: Prophage side tail fiber protein
• UniProt Gene Name: TFRC
• UniProt Synonym Gene Names: TR; TfR; TfR1; Trfr; sTfR

NCBI Description

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Uniprot Description

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome

Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity

Biological Process: positive regulation of B cell proliferation; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell proliferation; transferrin transport

Disease: Immunodeficiency 46