Human transcription factor AP-2 beta (activating enhancer binding protein 2 beta) ELISA Kit | TFAP2B elisa kit
Human Transcription factor AP-2-beta, TFAP2B ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]
Uniprot Description
AP-2 beta: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: nucleus
Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; caspase inhibitor activity; transcription coactivator activity; chromatin binding; transcription corepressor activity; transcription factor activity
Biological Process: fat cell differentiation; transcription from RNA polymerase II promoter; skin development; hindlimb morphogenesis; positive regulation of transcription, DNA-dependent; response to lithium ion; regulation of BMP signaling pathway; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; forelimb morphogenesis; calcium ion homeostasis; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; regulation of cell differentiation; positive regulation of neuron apoptosis; positive regulation of cell proliferation; sodium ion homeostasis; negative regulation of neuron apoptosis; phosphate ion homeostasis; kidney development; potassium ion homeostasis; response to drug; glucose metabolic process; renal water homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of insulin secretion; negative regulation of apoptosis
Disease: Char Syndrome
Research Articles on TFAP2B
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Product Notes
The Human TFAP2B tfap2b (Catalog #AAA9330202) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330202 ELISA Kit recognizes Human TFAP2B. It is sometimes possible for the material contained within the vial of "transcription factor AP-2 beta (activating enhancer binding protein 2 beta), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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