Rabbit anti-Human RNF41 Polyclonal Antibody | anti-RNF41 antibody

RNF41 (E3 Ubiquitin-protein Ligase NRDP1, RING Finger Protein 41, FLRF, NRDP1, SBBI03) (HRP)

Cat. Num. AAA6392775

• Gene Names: RNF41; FLRF; NRDP1; SBBI03
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: RNF41; Polyclonal Antibody; RNF41 (E3 Ubiquitin-protein Ligase NRDP1; RING Finger Protein 41; FLRF; NRDP1; SBBI03) (HRP); anti-RNF41 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RNF41.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).
• Sequence Length: 317

• Applicable Applications for anti-RNF41 antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full-length human RNF41, aa1-317.
• Immunogen Sequence: MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQTRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis of RNF41 expression in human kidney, using 132698.)

Western Blot (WB)

(Western Blot analysis of RNF41 expression in transfected 293T cell line, using 132698. Lane 1: RNF41 transfected lysate (35.9kD). Lane 2: Non-transfected lysate)

Related Product Information for anti-RNF41 antibody

Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages. Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resulting in a reduction of PARK2 activity, influencing the balance of intracellular redox state.

Product Categories/Family for anti-RNF41 antibody

Antibodies; Transcription Factors; Zinc (Ring) Finger

NCBI and Uniprot Product Information

• NCBI GI #: 5032071
• NCBI GeneID: 10193
• NCBI Accession #: NP_005776.1
• NCBI GenBank Nucleotide #: NM_005785.2
• UniProt Accession #: Q9H4P4
• NCBI Official Full Name: E3 ubiquitin-protein ligase NRDP1 isoform 1
• NCBI Official Synonym Full Names: ring finger protein 41
• NCBI Official Symbol: RNF41
• NCBI Official Synonym Symbols: FLRF; NRDP1; SBBI03
• NCBI Protein Information: E3 ubiquitin-protein ligase NRDP1
• UniProt Protein Name: E3 ubiquitin-protein ligase NRDP1
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: RNF41
• UniProt Synonym Gene Names: FLRF; NRDP1
• UniProt Entry Name: RNF41_HUMAN

NCBI Description

This gene encodes an E3 ubiquitin ligase. The encoded protein plays a role in type 1 cytokine receptor signaling by controlling the balance between JAK2-associated cytokine receptor degradation and ectodomain shedding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]