TES recombinant protein

TES, 1-421aa, Human, His tag, E Coli

Cat. Num. AAA203683

• Gene Names: TES; TESS; TESS-2
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: TES; 1-421aa; Human; His tag; E Coli; Testin; TESS; TESS-2; TES recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 10% glycerol
• Concentration: 0.5 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MDLENKVKKM GLGHEQGFGA PCLKCKEKCE GFELHFWRKI CRNCKCGQEE HDVLLSNEED RKVGKLFEDT KYTTLIAKLK SDGIPMYKRN VMILTNPVAA KKNVSINTVT YEWAPPVQNQ ALARQYMQML PKEKQPVAGS EGAQYRKKQL AKQLPAHDQD PSKCHELSPR EVKEMEQFVK KYKSEALGVG DVKLPCEMDA QGPKQMNIPG GDRSTPAAVG AMEDKSAEHK RTQYSCYCCK LSMKEGDPAI YAERAGYDKL WHPACFVCST CHELLVDMIY FWKNEKLYCG RHYCDSEKPR CAGCDELIFS NEYTQAENQN WHLKHFCCFD CDSILAGEIY VMVNDKPVCK PCYVKNHAVV CQGCHNAIDP EVQRVTYNNF SWHASTECFL CSCCSKCLIG QKFMPVEGMV FCSVECKKRM S
• Sequence Length: 421

• Applicable Applications for TES recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for TES recombinant protein

TES is a tumor suppressor protein and may play role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. This protein localizes to cell-cell contacts and actin stress fibres, and interacts with a variety of cytoskeletal proteins including Zyxin, Mena, VASP, Talin and Actin. The ability of TES to associate with alpha-actinin, paxillin and Zyxin is dependent on the conformational state of the molecule. Recombinant human TES protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for TES recombinant protein

Cancer

References

Qiu H., et al. (2010) Cancer Sci. 101 (5):1255-60.; Sato T., et al. (2003) J Biol Chem. 278 (48):47534-44.;

NCBI and Uniprot Product Information

• NCBI GI #: 7661666
• NCBI GeneID: 26136
• NCBI Accession #: NP_056456
• NCBI GenBank Nucleotide #: NM_015641.3
• UniProt Accession #: Q9UGI8; Q9GZQ1; Q9HAJ9; A4D0U6
• Molecular Weight: 50.1 kDa (441aa), confirmed by MALDI-TOF
• NCBI Official Full Name: testin isoform 1
• NCBI Official Synonym Full Names: testin LIM domain protein
• NCBI Official Symbol: TES
• NCBI Official Synonym Symbols: TESS; TESS-2
• NCBI Protein Information: testin
• UniProt Protein Name: Testin
• Protein Family: Tesmin
• UniProt Gene Name: TES

NCBI Description

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]

Uniprot Description

Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth.