F-box-like/WD repeat-containing protein TBL1X (Tbl1x) Recombinant Protein | Tbl1x recombinant protein

Recombinant Mouse F-box-like/WD repeat-containing protein TBL1X (Tbl1x)

Cat. Num. AAA1414543

• Gene Names: Tbl1x; Tbl1; 5330429M20
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: F-box-like/WD repeat-containing protein TBL1X (Tbl1x); Recombinant Mouse F-box-like/WD repeat-containing protein TBL1X (Tbl1x); Tbl1x recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-527, Full length protein
• Sequence: MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSKPMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
• Sequence Length: 527

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for Tbl1x recombinant protein

This protein has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. This encoded protein is found as a subunit in corepressor SMRT (silencing mediator for retinoid and thyroid receptors) complex along with histone deacetylase 3 protein. This gene is located adjacent to the ocular albinism gene and it is thought to be involved in the pathogenesis of the ocular albinism with late-onset sensorineural deafness phenotype. Four transcript variants encoding two different isoforms have been found for this gene. This gene is highly similar to the Y chromosome TBL1Y gene.

NCBI and Uniprot Product Information

• NCBI GI #: 33468969
• NCBI GeneID: 21372
• NCBI Accession #: NP_065626.1
• NCBI GenBank Nucleotide #: NM_020601.2
• UniProt Accession #: Q9QXE7; Q8BMM0; Q8BYQ4; Q8C0A1
• Molecular Weight: 56,802 Da
• NCBI Official Full Name: F-box-like/WD repeat-containing protein TBL1X
• NCBI Official Synonym Full Names: transducin (beta)-like 1 X-linked
• NCBI Official Symbol: Tbl1x
• NCBI Official Synonym Symbols: Tbl1; 5330429M20
• NCBI Protein Information: F-box-like/WD repeat-containing protein TBL1X
• UniProt Protein Name: F-box-like/WD repeat-containing protein TBL1X
• Protein Family: F-box-like/WD repeat-containing protein
• UniProt Gene Name: Tbl1x
• UniProt Synonym Gene Names: Tbl1

Uniprot Description

F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange ().