Tubulin-specific chaperone D (TBCD) Recombinant Protein | TBCD recombinant protein

Recombinant Chicken Tubulin-specific chaperone D (TBCD), partial

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Tubulin-specific chaperone D (TBCD); Recombinant Chicken Tubulin-specific chaperone D (TBCD); partial; TBCD recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,019

• Species: Chicken
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for TBCD recombinant protein

Cofactor D is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D
beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state.

NCBI and Uniprot Product Information

• NCBI GI #: 61098312
• NCBI GeneID: 417334
• NCBI Accession #: NP_001012819.1
• NCBI GenBank Nucleotide #: NM_001012801.1
• UniProt Accession #: Q5ZI87
• Molecular Weight: 113,662 Da
• NCBI Official Full Name: tubulin-specific chaperone D
• NCBI Official Synonym Full Names: tubulin folding cofactor D
• NCBI Official Symbol: TBCD
• NCBI Protein Information: tubulin-specific chaperone D
• UniProt Protein Name: Tubulin-specific chaperone D
• Protein Family: Tubulin-specific chaperone
• UniProt Gene Name: TBCD

Uniprot Description

Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis.