Mouse TAR DNA-binding protein 43 ELISA Kit | Tardbp elisa kit

Mouse TAR DNA-binding protein 43 ELISA Kit

Cat. Num. AAA2886155

• Gene Names: Tardbp; Tdp43; C85084; TDP-43; 1190002A23Rik
• Reactivity: Mouse
• Synonyms: TAR DNA-binding protein 43; Mouse TAR DNA-binding protein 43 ELISA Kit; TDP-43; Tardbp; Tdp43; Tardbp elisa kit

• Reactivity: Mouse
• Sequence Length: 295

• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 56682931
• NCBI GeneID: 230908
• NCBI Accession #: NP_001003899.1
• NCBI GenBank Nucleotide #: NM_001003899.2
• UniProt Accession #: Q921F2; Q3U591; Q3V0E7
• Molecular Weight: 44,548 Da
• NCBI Official Full Name: TAR DNA-binding protein 43 isoform 3
• NCBI Official Synonym Full Names: TAR DNA binding protein
• NCBI Official Symbol: Tardbp
• NCBI Official Synonym Symbols: Tdp43; C85084; TDP-43; 1190002A23Rik
• NCBI Protein Information: TAR DNA-binding protein 43
• UniProt Protein Name: TAR DNA-binding protein 43
• Protein Family: TAR DNA-binding protein
• UniProt Gene Name: Tardbp
• UniProt Synonym Gene Names: Tdp43; TDP-43
• UniProt Entry Name: TADBP_MOUSE

Uniprot Description

TARDBP: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Homodimer. Binds specifically to pyrimidine-rich motifs of TAR DNA and to single stranded TG repeated sequences. Binds to RNA, specifically to UG repeated sequences with a minimun of six contiguous repeats. Interacts with ATNX2; the interaction is RNA-dependent. Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding

Cellular Component: nucleoplasm; nucleus

Molecular Function: DNA binding; double-stranded DNA binding; identical protein binding; mRNA 3'-UTR binding; nucleic acid binding; nucleotide binding; protein binding; RNA binding

Biological Process: mRNA processing; negative regulation of protein amino acid phosphorylation; nuclear fragmentation during apoptosis; regulation of cell cycle; regulation of transcription, DNA-dependent; RNA splicing; transcription, DNA-dependent