Mouse TAO kinase 2 ELISA Kit | TAOK2 elisa kit
Mouse Serine/threonine-protein kinase TAO2, TAOK2 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
TAO2: a serine/threonine-protein kinase of the STE20 family. Activates the p38 MAPK signaling pathway through the specific activation of the upstream kinases MKK3 and MKK6. A potential multi-pass membrane protein. Activated in the DNA damage response and regulates the G2/M transition DNA damage checkpoint. Interacts with tubulins through the C-terminal domain. Involved in apoptotic processes such as membrane blebbing and apoptotic body formation. Prevents TAK1-mediated activation of IKK-alpha, and thus NF-kappa-B activation. May play a role in the osmotic stress-JNK1 pathway. An autism spectrum disorder susceptibility gene. Affects basal dendrite formation and axonal projections in cortical pyramidal neurons. Interacts with NRP1 (neuropilin 1), a receptor for the secreted guidance protein semaphorin 3A (Sema3A). Influences the formation of basal dendrites through the activation of JNK. Three isoforms of the human protein are produced by alternative splicing. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus. Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; Kinase, protein; Apoptosis; EC 2.7.11.1; STE group; STE20 family; TAO subfamily
Cellular Component: cell projection; cytoskeleton; membrane; cytoplasm; cytoplasmic membrane-bound vesicle; integral to membrane; nucleolus; cytoplasmic vesicle; nucleus; receptor complex
Molecular Function: transferase activity; protein serine/threonine kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; ATP binding; protein kinase activity
Biological Process: focal adhesion formation; activation of MAPKK activity; stress-activated MAPK cascade; MAPKKK cascade; positive regulation of JNK cascade; protein amino acid phosphorylation; positive regulation of stress-activated MAPK cascade; regulation of cell shape; response to stress; actin cytoskeleton organization and biogenesis; G2/M transition DNA damage checkpoint; response to DNA damage stimulus; phosphorylation
Research Articles on TAOK2
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Product Notes
The Mouse TAOK2 taok2 (Catalog #AAA9333554) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333554 ELISA Kit recognizes Mouse TAOK2. It is sometimes possible for the material contained within the vial of "TAO kinase 2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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