Mouse TRAF family member-associated NFKB activator ELISA Kit | TANK elisa kit

Mouse TRAF family member-associated NF-kappa-B activator, TANK ELISA Kit

Cat. Num. AAA9333166

• Gene Names: Tank; C86182; I-TRAF; E430026L09Rik
• Reactivity: Mouse
• Synonyms: TRAF family member-associated NFKB activator; Mouse TRAF family member-associated NF-kappa-B activator; TANK ELISA Kit; Mouse TRAF family member-associated NF-kappa-B activator (TANK) ELISA kit; I-TRAF; TRAF2; TRAF family member-associated NF-KAPPA-B activator; TRAF interacting protein TANK; TANK elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 255759991
• NCBI GeneID: 21353
• NCBI Accession #: NP_001157544.1
• NCBI GenBank Nucleotide #: NM_001164072.1
• UniProt Accession #: P70347; Q61178
• Molecular Weight: 50,939 Da
• NCBI Official Full Name: TRAF family member-associated NF-kappa-B activator isoform 2
• NCBI Official Synonym Full Names: TRAF family member-associated Nf-kappa B activator
• NCBI Official Symbol: Tank
• NCBI Official Synonym Symbols: C86182; I-TRAF; E430026L09Rik
• NCBI Protein Information: TRAF family member-associated NF-kappa-B activator; TRAF-interacting protein
• UniProt Protein Name: TRAF family member-associated NF-kappa-B activator
• Protein Family: TRAF family member-associated NF-kappa-B activator
• UniProt Gene Name: Tank
• UniProt Synonym Gene Names: Itraf; I-TRAF
• UniProt Entry Name: TANK_MOUSE

Uniprot Description

TANK: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits TRAF2-mediated NF- kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity. Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Ubiquitous. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; C2H2-type zinc finger protein

Cellular Component: cytoplasm; intracellular

Molecular Function: protein binding; metal ion binding; ubiquitin protein ligase binding

Biological Process: I-kappaB kinase/NF-kappaB cascade