E3 ubiquitin-protein ligase synoviolin (Syvn1) Recombinant Protein | Syvn1 recombinant protein
Recombinant Mouse E3 ubiquitin-protein ligase synoviolin (Syvn1)
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
Uniprot Description
SYVN1: Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Belongs to the HRD1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Ubiquitin conjugating system; Membrane protein, integral; EC 6.3.2.19; EC 6.3.2.-; Endoplasmic reticulum; Ligase; Ubiquitin ligase
Cellular Component: endoplasmic reticulum; integral to membrane; membrane; nucleoplasm; smooth endoplasmic reticulum; ubiquitin ligase complex
Molecular Function: ATPase binding; chaperone binding; coenzyme F420-0 gamma-glutamyl ligase activity; coenzyme F420-2 alpha-glutamyl ligase activity; ligase activity; metal ion binding; protein binding; ribosomal S6-glutamic acid ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; unfolded protein binding; zinc ion binding
Biological Process: ER-associated protein catabolic process; in utero embryonic development; multicellular organismal development; protein amino acid N-linked glycosylation via asparagine; protein catabolic process; protein polyubiquitination; protein stabilization; protein ubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process; response to unfolded protein; retrograde protein transport, ER to cytosol; unfolded protein response
Research Articles on Syvn1
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Product Notes
The Syvn1 syvn1 (Catalog #AAA7030780) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 23-612aa; full length protein. This is a recombinant transmembrane protein expressed in a cell-free expression system. Researchers should empirically determine the suitability of the Syvn1 syvn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: YYLKHQFYPT VVYLTKSSPS MAVLYIQAFV LVFLLGKVMG KVFFGQLRAA EMEHLLERSW YAVTETCLAF TVFRDDFSPR FVALFTLLLF LKCFHWLAED RVDFMERSPN ISWLFHCRIV SLMFLLGILD FLFVSHAYHS ILTRGASVQL VFGFEYAILM TMVLTIFIKY VLHSVDLQSE NPWDNKAVYM LYTELFTGFI KVLLYMAFMT IMIKVHTFPL FAIRPMYLAM RQFKKAVTDA IMSRRAIRNM NTLYPDATPE ELQAVDNVCI ICREEMVTGA KRLPCNHIFH TSCLRSWFQR QQTCPTCRMD VLRASLPAQS PPPPEPADQG PPPAPHPQPL LPQPPNFPQG LLPPFPPGMF PLWPPMGPFP PVPPPPSSGE AAAPPPTSTA VSRPSGAATT TAAGTSTSAP APGSVPGPEA GPAPGFPFPP PWMGMPLPPP FAFPPMPVPP AGFAGLTPEE LRALEGHERQ HLEARLQSLR NIHTLLDAAM LQINQYLTVL ASLGPPRPAT SVNPTEETAS TVVSAAPSTS APSSEAPTPS PGASPPIPEA EKPPAPESVG IVEELPEDGE PDAAELRRRR LQKLESPVAH. It is sometimes possible for the material contained within the vial of "E3 ubiquitin-protein ligase synoviolin (Syvn1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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