Rabenosyn 5 Blocking Peptide | ZFYVE20 blocking peptide

Rabenosyn 5 Blocking Peptide

Cat. Num. AAA8243943

• Gene Names: RBSN; ZFYVE20; Rabenosyn-5
• Reactivity: Human, Mouse
• Applications: Blocking (BL)
• Purity: >85%
• Synonyms: Rabenosyn 5; Rabenosyn 5 Blocking Peptide; Rabenosyn-5; 110 kDa protein; FYVE finger-containing Rab5 effector protein rabenosyn-5; Zinc finger FYVE domain-containing protein 20; ZFYVE20 blocking peptide

• Host: Synthetic
• Reactivity: Human, Mouse
• Purity/Purification: >85%
• Form/Format: Lyophilized Powder
• Sequence Length: 784

• Applicable Applications for ZFYVE20 blocking peptide: Blocking (BL)
• Application Notes: Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
• Quality Control: The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for ZFYVE20 blocking peptide

The peptide is used to block Anti-Rabenosyn 5 Antibody reactivity.

NCBI and Uniprot Product Information

• NCBI GI #: 108935884
• NCBI GeneID: 64145
• UniProt Accession #: Q9H1K0; Q3KP30; Q59EY8; Q8NAQ1; B4DWY8; C9J4P5
• Molecular Weight: 23,794 Da
• NCBI Official Full Name: Rabenosyn-5
• NCBI Official Synonym Full Names: rabenosyn, RAB effector
• NCBI Official Symbol: RBSN
• NCBI Official Synonym Symbols: ZFYVE20; Rabenosyn-5
• NCBI Protein Information: rabenosyn-5
• UniProt Protein Name: Rabenosyn-5
• UniProt Gene Name: RBSN
• UniProt Entry Name: RBNS5_HUMAN

NCBI Description

This gene encodes a protein that belongs to the FYVE zinc finger family of proteins. The encoded protein interacts with Ras-related proteins that regulate membrane trafficking. A missense mutation in this gene is associated with a defect in the early endocytic pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Uniprot Description

ZFYVE20: Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).

Protein type: Adaptor/scaffold; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 3p25.1

Cellular Component: early endosome membrane; endosome; endosome membrane; intracellular membrane-bound organelle; plasma membrane

Molecular Function: protein binding; Rab GTPase binding; zinc ion binding

Biological Process: blood coagulation; endocytosis; endosomal vesicle fusion; endosome transport; Golgi to endosome transport; Golgi to vacuole transport; late endosome to vacuole transport; protein transport; vacuole inheritance