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TIF1 alpha Blocking Peptide | TRIM24 blocking peptide

TIF1 alpha Blocking Peptide

Gene Names
TRIM24; PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA
Reactivity
Human, Bovine, Dog, Monkey, Pig
Applications
Blocking (BL)
Purity
>85%
Synonyms
TIF1 alpha; TIF1 alpha Blocking Peptide; RNF82; TIF1; TIF1A; Transcription intermediary factor 1-alpha; TIF1-alpha; E3 ubiquitin-protein ligase TRIM24; RING finger protein 82; Tripartite motif-containing protein 24; TRIM24 blocking peptide
Ordering
For Research Use Only!
Host
Synthetic
Reactivity
Human, Bovine, Dog, Monkey, Pig
Purity/Purification
>85%
Form/Format
Lyophilized powder
Sequence Length
1016
Applicable Applications for TRIM24 blocking peptide
Blocking (BL)
Application Notes
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Related Product Information for TRIM24 blocking peptide
The peptide is used to block Anti-TIF1 alpha Antibody reactivity.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
113,018 Da
NCBI Official Full Name
transcription intermediary factor 1-alpha isoform b
NCBI Official Synonym Full Names
tripartite motif containing 24
NCBI Official Symbol
TRIM24
NCBI Official Synonym Symbols
PTC6; TF1A; TIF1; RNF82; TIF1A; hTIF1; TIF1ALPHA
NCBI Protein Information
transcription intermediary factor 1-alpha; TIF1-alpha; RING finger protein 82; tripartite motif-containing 24; E3 ubiquitin-protein ligase TRIM24; transcriptional intermediary factor 1
UniProt Protein Name
Transcription intermediary factor 1-alpha
UniProt Gene Name
TRIM24
UniProt Synonym Gene Names
RNF82; TIF1; TIF1A; TIF1-alpha
UniProt Entry Name
TIF1A_HUMAN

NCBI Description

The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TRIM24: an atypical protein kinase that functions as a transcriptional coactivator. Originally identified as a mammalian protein that enhances the AF-2 activity of the retinoid X receptor (RXR) in a yeast genetic screen. Binds to nuclear receptors in an agonist and AF2-activating domain (AF2-AD) dependent manner. Binding to the agonist-nuclear receptor complex induces its own hyperphosphorylation as well as the phosphorylation of TFIIEa, TAFII28, and TAFII55. Belongs to a family of nuclear proteins that includes TIF1b and TIF1g. TIF1 proteins are characterized by an N-terminal region that contains a RING finger-B boxes-coiled coil (RBCC) motif, a poorly conserved central region, a C-terminal region that contains a PHD finger, and a bromodomain. Interacts with the heterochromatin-associated proteins HP1a, MOD1 (HP1b), and MOD2 (HP1g) and with the transcriptional repression domain KRAB, which is present in many Kruppel-type (C2H2) zinc finger proteins. May act as a repressor through the formation of transcriptionally inactive heterochromatin. Two splice variant isoforms have been described.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Ubiquitin conjugating system; EC 6.3.2.-; Tumor suppressor; Protein kinase, atypical; Kinase, protein; ATYPICAL group; TIF1 family

Chromosomal Location of Human Ortholog: 7q32-q34

Cellular Component: nucleoplasm; perichromatin fibrils; cytosol; nucleus

Molecular Function: ligand-dependent nuclear receptor binding; protein binding; zinc ion binding; p53 binding; sequence-specific DNA binding; transcription coactivator activity; ubiquitin-protein ligase activity; estrogen response element binding; chromatin binding; methylated histone residue binding; protein kinase activity; ligase activity; receptor binding

Biological Process: calcium ion homeostasis; transcription from RNA polymerase II promoter; regulation of apoptosis; response to peptide hormone stimulus; negative regulation of cell proliferation; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; protein ubiquitination; regulation of protein stability; protein catabolic process; negative regulation of transcription, DNA-dependent

Disease: Thyroid Carcinoma, Papillary

Research Articles on TRIM24

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Product Notes

The TRIM24 trim24 (Catalog #AAA822757) is a Blocking Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The TIF1 alpha Blocking Peptide reacts with Human, Bovine, Dog, Monkey, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's TIF1 alpha can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours. Researchers should empirically determine the suitability of the TRIM24 trim24 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIF1 alpha, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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