SLC34A2 sirna
SLC34A2 siRNA (Rat)
NCBI and Uniprot Product Information
NCBI Description
may act as a sodium dependent phosphate transporter; may provide inorganic phosphate for the synthesis of lung surfactant [RGD, Feb 2006]
Uniprot Description
SLC34A2: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM). Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. A chromosomal aberration involving SLC34A2 is found in a non-small cell lung cancer cell line. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transporter, SLC family; Transporter; Membrane protein, multi-pass; Membrane protein, integral
Cellular Component: microvillus membrane; brush border membrane; apical plasma membrane; integral to membrane; brush border; vesicle
Molecular Function: protein domain specific binding; sodium ion binding; phosphate binding; sodium-dependent phosphate transmembrane transporter activity; sodium:phosphate symporter activity
Biological Process: cellular phosphate ion homeostasis; phosphate transport; response to estrogen stimulus; in utero embryonic development; response to fructose stimulus; response to estradiol stimulus; aging