NCBI Description
This gene encodes a member of the aconitase/IPM isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Depending on iron levels in the cytosol, the encoded protein can function as either an aconitase enzyme or as an mRNA binding protein. When cellular iron levels are high, the encoded protein functions as an aconitase, an essential enzyme in the TCA cycle that catalyzes the conversion of citrate to isocitrate. When cellular iron levels are low, the encoded protein regulates iron uptake and utilization by binding to iron-responsive elements in the untranslated regions of mRNAs for genes involved in iron metabolism [provided by RefSeq, Jan 2014]
Uniprot Description
IREB1: Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Belongs to the aconitase/IPM isomerase family.
Protein type: EC 4.2.1.3; RNA-binding; Lyase; Endoplasmic reticulum; Translation; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - citrate (TCA) cycle
Cellular Component: Golgi apparatus; mitochondrion; intracellular membrane-bound organelle; cell; endoplasmic reticulum; cytoplasm; cytosol
Molecular Function: mRNA binding; iron-responsive element binding; RNA binding; metal ion binding; 4 iron, 4 sulfur cluster binding; iron-sulfur cluster binding; mRNA 5'-UTR binding; aconitate hydratase activity
Biological Process: regulation of translation; regulation of gene expression; cellular iron ion homeostasis; tricarboxylic acid cycle; citrate metabolic process; response to iron(II) ion; post-embryonic development; intestinal absorption
Product Notes
The ACO1 aco1 (Catalog #
AAA8234308) is a siRNA produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The ACO1 siRNA (Rat) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ACO1 can be used in a range of immunoassay formats including, but not limited to, RNA Interference (RNAi). Researchers should empirically determine the suitability of the ACO1 aco1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"ACO1, siRNA" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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