Protein Kinase C, Substrate Peptide | PACSIN2 peptide
Protein Kinase C, Substrate Peptide (PKC)
97% determined by HPLC
97% determined by HPLC
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Description
Function: Plays a role in the formation of normal, flask-shaped caveolae at the cell membrane. Recruits DNM2 to caveolae, and thereby plays a role in caveola-mediated endocytosis. Plays a role in intracellular vesicle-mediated transport. Binds to membranes via its F-BAR domain and promotes membrane tubulation. Plays a role in the internalization of cell-surface receptors. Is not required for internalization of EGFR after EGF stimulus, but contributes to the internalization of EGFR in the absence of EGF stimulus. Ref.12 Ref.13 Ref.15 Ref.16
Subunit structure: Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYN1, SYNJ1 and WASL. Interacts with EHD1 and EHD3. Interacts with CAV1. Interacts with TRPV4
By similarity. Interacts with RAC1. Ref.13
Subcellular location: Cytoplasm
By similarity. Cytoplasm › cytoskeleton
By similarity. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cell projection › ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection
By similarity. Membrane › caveola. Note: Detected at the neck of flask-shaped caveolae. Ref.12 Ref.13 Ref.15
Tissue specificity: Widely expressed. Ref.7 Ref.8
Domain: The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation. In the autoinhibited conformation, interaction with the SH3 domain inhibits membrane tubulation mediated by the F-BAR domain. Ref.12 Ref.16 Ref.17 Ref.18
Post-translational modification: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC)
By similarity.
Sequence similarities: Belongs to the PACSIN family.Contains 1 FCH domain.Contains 1 SH3 domain.
Research Articles on PACSIN2
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Product Notes
The PACSIN2 pacsin2 (Catalog #AAA659117) is a Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Protein Kinase C, Substrate Peptide, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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