CFTR peptide
CFTR (108-117)
NCBI and Uniprot Product Information
NCBI Description
cAMP-activated chloride channel and ATP binding cassette (ABC) transporter involved in intestinal anion secretion [RGD, Feb 2006]
Uniprot Description
CFTR: a member of the MRP subfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. Functions as a chloride channel and controls the regulation of other transport pathways. Mutations have been observed in patients with the autosomal recessive disorders cystic fibrosis (CF) and congenital bilateral aplasia of the vas deferens (CBAVD). Alternative splice
Protein type: EC 3.6.3.49; Channel, chloride; Hydrolase; Transporter, ABC family; Membrane protein, multi-pass; Membrane protein, integral; Transporter
Cellular Component: apical plasma membrane; basolateral plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle membrane; cytosol; early endosome; early endosome membrane; microvillus; plasma membrane; protein complex; recycling endosome
Molecular Function: ATP binding; bicarbonate transmembrane transporter activity; channel-conductance-controlling ATPase activity; chloride channel activity; chloride channel inhibitor activity; chloride transmembrane transporter activity; enzyme binding; PDZ domain binding
Biological Process: bicarbonate transport; body fluid secretion; cellular response to hormone stimulus; chloride transport; cholesterol biosynthetic process; cholesterol transport; intracellular pH elevation; iodide transport; lung development; membrane hyperpolarization; positive regulation of exocytosis; positive regulation of vasodilation; response to cytokine stimulus; response to drug; response to estrogen stimulus; response to peptide hormone stimulus; sperm capacitation; transepithelial chloride transport; vasodilation; vesicle docking during exocytosis; water transport
Research Articles on CFTR
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Product Notes
The CFTR cftr (Catalog #AAA8246351) is a Peptide produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Ser-Tyr-As p-Pro-Asp- Asn-Lys-Gl u-Glu-Arg. It is sometimes possible for the material contained within the vial of "CFTR, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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