Endothelin [Cyclo-Gly-Asn-Trp-His-Gly-Thr-Ala-Pr-Beta-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp] Peptide | EDNRB peptide
Endothelin [Cyclo-Gly-Asn-Trp-His-Gly-Thr-Ala-Pr-Beta-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp]
~95%. Purified by HPLC.
~95%. Purified by HPLC.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Description
Function: Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Ref.8
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. Ref.19
Post-translational modification: Palmitoylation of Cys-402 was confirmed by the palmitoylation of Cys-402 in a deletion mutant lacking both Cys-403 and Cys-405. Ref.20
Involvement in disease: Waardenburg syndrome 4A (WS4A) [MIM:277580]: A disorder characterized by the association of Waardenburg features (depigmentation and deafness) with the absence of enteric ganglia in the distal part of the intestine (Hirschsprung disease).Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23 Ref.30Hirschsprung disease 2 (HSCR2) [MIM:600155]: A disorder of neural crest development characterized by absence of enteric ganglia along a variable length of the intestine. It is the most common cause of congenital intestinal obstruction. Early symptoms range from complete acute neonatal obstruction, characterized by vomiting, abdominal distention and failure to pass stool, to chronic constipation in the older child.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.22 Ref.24 Ref.25 Ref.26 Ref.28ABCD syndrome (ABCDS) [MIM:600501]: An autosomal recessive syndrome characterized by albinism, black lock at temporal occipital region, bilateral deafness, aganglionosis of the large intestine and total absence of neurocytes and nerve fibers in the small intestine.Note: The disease is caused by mutations affecting the gene represented in this entry.
Sequence similarities: Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
Sequence caution: The sequence BAD92435.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on EDNRB
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Product Notes
The EDNRB ednrb (Catalog #AAA658612) is a Peptide produced from Synthetic peptide and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Cyclo(-Gly -Asn-Trp-H is-Gly-Thr -Ala-Pro- BETA -Asp)-Trp- Phe-Phe-As n-Tyr-Tyr- Trp. It is sometimes possible for the material contained within the vial of "Endothelin [Cyclo-Gly-Asn-Trp-His-Gly-Thr-Ala-Pr-Beta-Asp-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp], Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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