Cyclic GMP Peptide | KCNA10 peptide

Cyclic GMP (cGMP) Protein Kinase Substrate [Arg-Lys-Arg-Ser-Arg-Ala-Glu](cGMP)

Cat. Num. AAA658309

• Gene Names: KCNA10; Kcn1; Kv1.8
• Purity: Highly Purified; ~95%. Purified by HPLC.
• Synonyms: Cyclic GMP; Cyclic GMP (cGMP) Protein Kinase Substrate [Arg-Lys-Arg-Ser-Arg-Ala-Glu](cGMP); KCNA10 peptide

• Host: Synthetic peptide
• Purity/Purification: Highly Purified; ~95%. Purified by HPLC.
• Form/Format: Supplied as a lyophilized powder.

• Sequence (linear): Arg-Lys-Arg-Ser-Arg-Ala-Glu; Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for KCNA10 peptide

Molecular Biology; MB-Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 2138345
• NCBI GeneID: 3744
• UniProt Accession #: Q16322
• Molecular Weight: 57,785 Da
• NCBI Official Full Name: cyclic GMP gated potassium channel
• NCBI Official Synonym Full Names: potassium voltage-gated channel, shaker-related subfamily, member 10
• NCBI Official Symbol: KCNA10
• NCBI Official Synonym Symbols: Kcn1; Kv1.8
• NCBI Protein Information: potassium voltage-gated channel subfamily A member 10; cyclic GMP gated potassium channel; voltage-gated potassium channel subunit Kv1.8
• UniProt Protein Name: Potassium voltage-gated channel subfamily A member 10
• Protein Family: Cyclic GMP-AMP synthase
• UniProt Gene Name: KCNA10
• UniProt Entry Name: KCA10_HUMAN

NCBI Description

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1. [provided by RefSeq, Jul 2008]

Uniprot Description

Function: Mediates voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. The channel activity is up-regulated by cAMP. Ref.5

Subunit structure: Homotetramer. Interacts with KCN4B/POMP. Interaction with KCN4B/POMP is necessary for the modulation of channel activity by cAMP. Ref.6

Subcellular location: Membrane; Multi-pass membrane protein Ref.5.

Tissue specificity: Detected in kidney, in proximal tubules, glomerular endothelium, in vascular endothelium and in smooth muscle cells. Ref.7

Domain: The N-terminus may be important in determining the rate of inactivation of the channel while the tail may play a role in modulation of channel activity and/or targeting of the channel to specific subcellular compartments.The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.

Sequence similarities: Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.8/KCNA10 sub-subfamily. [View classification]