Atrial Natriuretic Peptide | NPPA peptide

Atrial Natriuretic Peptide (8-30) (frog) (ANP, Atrial Natriuretic Factor)

Cat. Num. AAA659849

• Gene Names: NPPA; ANF; ANP; PND; ATFB6; CDD-ANF
• Purity: Highly Purified; ~95%. Purified by HPLC.
• Synonyms: Atrial Natriuretic Peptide; Atrial Natriuretic Peptide (8-30) (frog) (ANP; Atrial Natriuretic Factor); NPPA peptide

• Host: Synthetic peptide
• Purity/Purification: Highly Purified; ~95%. Purified by HPLC.
• Form/Format: Supplied as a lyophilized powder.

• Sequence (linear): Ser-Ser-Asp-Cys-Phe-Gly-Ser-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Met-Gly-Cys-Gly-Arg-Phe
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for NPPA peptide

Molecular Biology; MB-Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 178638
• NCBI GeneID: 4878
• UniProt Accession #: P01160; Q13766; Q5JZE1
• Molecular Weight: 16,708 Da
• NCBI Official Full Name: atrial natriuretic peptide
• NCBI Official Synonym Full Names: natriuretic peptide A
• NCBI Official Symbol: NPPA
• NCBI Official Synonym Symbols: ANF; ANP; PND; ATFB6; CDD-ANF
• NCBI Protein Information: natriuretic peptides A; atriopeptin; cardionatrin; prepronatriodilatin; natriuretic peptide precursor A
• UniProt Protein Name: Natriuretic peptides A
• Protein Family: Atrial natriuretic peptide receptor
• UniProt Gene Name: NPPA
• UniProt Synonym Gene Names: ANP; PND; CDP; ANF; ANP
• UniProt Entry Name: ANF_HUMAN

NCBI Description

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]

Uniprot Description

Function: Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Ref.15

Subcellular location: Secreted.

Post-translational modification: Cleaved by CORIN upon secretion to produce the functional hormone.

Polymorphism: There are two different prepronatriodilatin alleles. One codes for 2 Arg residues at the C-terminus that are cleaved to form the mature peptide, while the other ends in a termination codon immediately after the last codon of the mature peptide.

Involvement in disease: Familial atrial fibrillation 6 (ATFB6) [MIM:612201]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.20

Sequence similarities: Belongs to the natriuretic peptide family.

Sequence caution: The sequence CAA15955.2 differs from that shown. Reason: Erroneous initiation.