ACTH, Tyr Peptide | AIP peptide

ACTH, Tyr (4-10) (POMC, Adrenocorticotropin, beta Lipotropin, alpha (beta) Melanocyte Stimulating Hormone, CLIP, Corticotropin-lipotropin precursor, LPH, MSH, NPP, POC, Pro-opiomelanocortin)

Cat. Num. AAA659771

• Gene Names: AIP; ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
• Purity: Highly Purified; ~95%. Purified by HPLC.
• Synonyms: ACTH; Tyr; Tyr (4-10) (POMC; Adrenocorticotropin; beta Lipotropin; alpha (beta) Melanocyte Stimulating Hormone; CLIP; Corticotropin-lipotropin precursor; LPH; MSH; NPP; POC; Pro-opiomelanocortin); AIP peptide

• Host: Synthetic peptide
• Purity/Purification: Highly Purified; ~95%. Purified by HPLC.
• Form/Format: Supplied as a lyophilized powder.

• Sequence (linear): Tyr-Met-Glu-His-Phe-Arg-Trp-Gly
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for AIP peptide

Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of corticosteroids. A deficiency of ACTH is a cause of secondary adrenal insufficiency and an excess of it is a cause of Cushing's disease.

Product Categories/Family for AIP peptide

Molecular Biology; MB-Peptides

NCBI and Uniprot Product Information

• NCBI GI #: 254763247
• NCBI GeneID: 9049
• UniProt Accession #: O00170; Q2M3Q2; Q99606; A0SZW3; A0SZW4; A0SZW5; A0SZW6
• Molecular Weight: 37,636 Da
• NCBI Official Full Name: AH receptor-interacting protein
• NCBI Official Synonym Full Names: aryl hydrocarbon receptor interacting protein
• NCBI Official Symbol: AIP
• NCBI Official Synonym Symbols: ARA9; XAP2; XAP-2; FKBP16; FKBP37; SMTPHN
• NCBI Protein Information: AH receptor-interacting protein; immunophilin homolog ARA9; HBV X-associated protein 2
• UniProt Protein Name: AH receptor-interacting protein
• Protein Family: AH receptor-interacting protein
• UniProt Gene Name: AIP
• UniProt Synonym Gene Names: XAP2; AIP; XAP-2
• UniProt Entry Name: AIP_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. [provided by RefSeq, Sep 2008]

Uniprot Description

Function: May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.Cellular negative regulator of the hepatitis B virus (HBV) X protein.

Subunit structure: Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex. Ref.9

Subcellular location: Cytoplasm.

Tissue specificity: Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Involvement in disease: Growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]: Pituitary adenomas include somatotropinoma and prolactinoma.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.4 Ref.8 Ref.10 Ref.11ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]: A pituitary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes.Note: The disease is caused by mutations affecting the gene represented in this entry.Prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]: Most common type of hormonally active pituitary adenoma.Note: The disease is caused by mutations affecting the gene represented in this entry.

Sequence similarities: Contains 1 PPIase FKBP-type domain.Contains 2 TPR repeats.