Endothelin 1 Peptide | EDN1 peptide
Endothelin 1 (Big) (1-39) (human)
Gene Names
EDN1; ET1; PPET1; HDLCQ7
Reactivity
Human
Purity
Highly Purified~95%. Purified by HPLC.
Synonyms
Endothelin 1; Endothelin 1 (Big) (1-39) (human); EDN1 peptide
Host
Synthetic peptide
Reactivity
Human
Purity/Purification
Highly Purified
~95%. Purified by HPLC.
~95%. Purified by HPLC.
Form/Format
Supplied as a lyophilized powder.
Sequence
Sequence (linear): Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Val-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Arg-Ser
Molecular Formula
C189 H286 N48 O56 S5
Warning
It is practically impossible to recover a peptide that has aggregated in the presence of salt. If sufficient peptide is available, test the solubility on a small sample first. Please not that DMSO can completely oxidize the free thiol groups of cysteine in short-chain peptides within minutes and should be avoided as a solvent for these peptides. Peptides containing Trp, Met, Cys, Asn or Gln require special car to avoid oxidation; oxygen free water should be used.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for EDN1 peptide
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms, ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart and liver.
Product Categories/Family for EDN1 peptide
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
4286.96
NCBI Official Full Name
endothelin-1
NCBI Official Synonym Full Names
endothelin 1
NCBI Official Symbol
EDN1
NCBI Official Synonym Symbols
ET1; PPET1; HDLCQ7
NCBI Protein Information
endothelin-1; preproendothelin-1
UniProt Protein Name
Endothelin-1
Protein Family
UniProt Gene Name
EDN1
UniProt Synonym Gene Names
PPET1; ET-1
UniProt Entry Name
EDN1_HUMAN
NCBI Description
The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent vasoconstrictor and is produced by vascular endothelial cells. Endothelin 1 also can affect the central nervous system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
Uniprot Description
Function: Endothelins are endothelium-derived vasoconstrictor peptides.
Subcellular location: Secreted.
Tissue specificity: Expressed in lung, placental stem villi vessels and in cultured placental vascular smooth muscle cells. Ref.11
Sequence similarities: Belongs to the endothelin/sarafotoxin family.
Research Articles on EDN1
Similar Products
Product Notes
The EDN1 edn1 (Catalog #AAA659983) is a Peptide produced from Synthetic peptide and is intended for research purposes only. The product is available for immediate purchase. The Endothelin 1 (Big) (1-39) (human) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: Sequence (linear): Cys-Ser-Cy s-Ser-Ser- Leu-Met-As p-Lys-Glu- Cys-Val-Ty r-Phe-Cys- His-Leu-As p-Ile-Ile- Trp-Val-As n-Thr-Pro- Glu-His-Va l-Val-Pro- Tyr-Gly-Le u-Gly-Ser- Pro-Arg-Se r. It is sometimes possible for the material contained within the vial of "Endothelin 1, Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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