Uniprot Description
VAMP2: a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Vesicle
Cellular Component: neuron projection; zymogen granule membrane; synaptic vesicle membrane; clathrin-coated vesicle; intracellular membrane-bound organelle; cell; integral to membrane; intracellular organelle; terminal button; trans-Golgi network; secretory granule; SNARE complex; synaptic vesicle; membrane; perinuclear region of cytoplasm; plasma membrane; synapse; cytoplasmic vesicle; intracellular; cell junction
Molecular Function: protein C-terminus binding; calmodulin binding; identical protein binding; SNAP receptor activity; protein binding; SNARE binding; syntaxin binding; myosin binding; syntaxin-1 binding; protein complex binding; phospholipid binding; calcium-dependent protein binding
Biological Process: vesicle fusion; regulation of exocytosis; vesicle-mediated transport; protein transport; synaptic vesicle exocytosis; cellular response to insulin stimulus; Golgi to plasma membrane protein transport; response to glucose stimulus; eosinophil degranulation; protein complex assembly; regulation of calcium ion-dependent exocytosis; calcium ion-dependent exocytosis
Product Notes
The VAMP2 vamp2 (Catalog #
AAA8200893) is a siRNA produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The VAMP2 siRNA (Mouse) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's VAMP2 can be used in a range of immunoassay formats including, but not limited to, RNA Interference (RNAi). Researchers should empirically determine the suitability of the VAMP2 vamp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"VAMP2, siRNA" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a
product from AAA Biotech, you
are explicitly certifying that said products will be properly tested and used in line with
industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech
cannot be held
responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any
aspect of this datasheet at
any time and without notice. It is the responsibility of the customer to inform AAA Biotech
of any product performance
issues observed or experienced within 30 days of receipt of said product. To see additional
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