TNFRSF23 sirna

TNFRSF23 siRNA (Mouse)

Cat. Num. AAA8222369

• Gene Names: Tnfrsf23; SOB; mSOB; Tnfrh1; TNFRSFH23; Tnfrsf1al1; mDcTRAILR1
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: TNFRSF23; TNFRSF23 siRNA (Mouse); DCTRAILR1; TNFRH1; TNFRSF1AL1; Tumor necrosis factor receptor superfamily member 23; Decoy TRAIL receptor 1; TNF receptor family member SOB; TNF receptor homolog 1; Tumor necrosis factor receptor p60 homolog 1; TNFRSF23 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: TNFRSF23 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 176

• Applicable Applications for TNFRSF23 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse TNFRSF23 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for TNFRSF23 sirna

siRNA to inhibit TNFRSF23 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 28269699
• NCBI GeneID: 79201
• NCBI Accession #: NP_077252.2
• NCBI GenBank Nucleotide #: NM_024290.4
• UniProt Accession #: Q9ER63; Q8VHC0
• Molecular Weight: 19,595 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 23 isoform 1
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 23
• NCBI Official Symbol: Tnfrsf23
• NCBI Official Synonym Symbols: SOB; mSOB; Tnfrh1; TNFRSFH23; Tnfrsf1al1; mDcTRAILR1
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 23
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 23
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: Tnfrsf23
• UniProt Synonym Gene Names: Dctrailr1; Tnfrh1; Tnfrsf1al1
• UniProt Entry Name: TNR23_MOUSE

NCBI Description

This gene encodes a member of the tumor necrosis factor superfamily of proteins. The encoded receptor has been shown to bind to the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), but to have no signaling capacity. This gene shows elevated expression in mice with diet-induced fatty liver disease. This gene and other family members are present in a gene cluster on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Uniprot Description

TNFRSF23: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis through ligand competition. Cannot induce the NF-kappa-B pathway.

Cellular Component: anchored to external side of plasma membrane; membrane; plasma membrane

Molecular Function: protein binding