TNFRSF12A sirna
TNFRSF12A siRNA (Mouse)
Gene Names
Tnfrsf12a; Fn14; HPIP; C87282; TweakR; TWEAK-R; AI255180
Reactivity
Mouse
Applications
RNA Interference (RNAi)
Purity
> 97%
Synonyms
TNFRSF12A; TNFRSF12A siRNA (Mouse); FGFRP2; FN14; Tumor necrosis factor receptor superfamily member 12A; Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Fibroblast growth factor-regulated protein 2; Tweak-receptor; TweakR; CD antigen CD266; TNFRSF12A sirna
Host
Synthetic
Reactivity
Mouse
Specificity
TNFRSF12A siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Purity/Purification
> 97%
Form/Format
Lyophilized powder
Sequence Length
94
Applicable Applications for TNFRSF12A sirna
RNA Interference (RNAi)
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse TNFRSF12A gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Related Product Information for TNFRSF12A sirna
siRNA to inhibit TNFRSF12A expression using RNA interference
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
13,641 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 12A isoform 2
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 12a
NCBI Official Symbol
Tnfrsf12a
NCBI Official Synonym Symbols
Fn14; HPIP; C87282; TweakR; TWEAK-R; AI255180
NCBI Protein Information
tumor necrosis factor receptor superfamily member 12A
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 12A
Protein Family
UniProt Gene Name
Tnfrsf12a
UniProt Synonym Gene Names
Fgfrp2; Fn14; FGF-inducible 14; TweakR
UniProt Entry Name
TNR12_MOUSE
Uniprot Description
TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis; Cell development/differentiation
Cellular Component: ruffle; cell surface; membrane; plasma membrane; integral to membrane
Molecular Function: protein binding
Biological Process: substrate-bound cell migration, cell attachment to substrate; positive regulation of apoptosis; apoptosis; positive regulation of axon extension; multicellular organismal development; angiogenesis; cell differentiation; cell adhesion; regulation of angiogenesis
Research Articles on TNFRSF12A
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Product Notes
The TNFRSF12A tnfrsf12a (Catalog #AAA8240570) is a siRNA produced from Synthetic and is intended for research purposes only. The product is available for immediate purchase. The TNFRSF12A siRNA (Mouse) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TNFRSF12A can be used in a range of immunoassay formats including, but not limited to, RNA Interference (RNAi). Researchers should empirically determine the suitability of the TNFRSF12A tnfrsf12a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFRSF12A, siRNA" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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