TGFBR3 sirna

TGFBR3 siRNA (Mouse)

Cat. Num. AAA8216496

• Gene Names: Tgfbr3; TBRIII; AU015626; AW215636; 1110036H20Rik
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: TGFBR3; TGFBR3 siRNA (Mouse); Transforming growth factor beta receptor type 3; TGF-beta receptor type 3; TGFR-3; Betaglycan; Transforming growth factor beta receptor III; TGF-beta receptor type III; TGFBR3 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: TGFBR3 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 850

• Applicable Applications for TGFBR3 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse TGFBR3 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for TGFBR3 sirna

siRNA to inhibit TGFBR3 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 47271511
• NCBI GeneID: 21814
• NCBI Accession #: NP_035708.2
• NCBI GenBank Nucleotide #: NM_011578.3
• UniProt Accession #: O88393; Q6NS72
• Molecular Weight: 93,829 Da
• NCBI Official Full Name: transforming growth factor beta receptor type 3
• NCBI Official Synonym Full Names: transforming growth factor, beta receptor III
• NCBI Official Symbol: Tgfbr3
• NCBI Official Synonym Symbols: TBRIII; AU015626; AW215636; 1110036H20Rik
• NCBI Protein Information: transforming growth factor beta receptor type 3
• UniProt Protein Name: Transforming growth factor beta receptor type 3
• Protein Family: Transforming growth factor
• UniProt Gene Name: Tgfbr3
• UniProt Synonym Gene Names: TGF-beta receptor type 3; TGFR-3; TGF-beta receptor type III
• UniProt Entry Name: TGBR3_MOUSE

Uniprot Description

TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; membrane; endoplasmic reticulum; integral to plasma membrane; cytoplasm; plasma membrane; extracellular region; integral to membrane; receptor complex; external side of plasma membrane

Molecular Function: transforming growth factor beta receptor activity; heparin binding; protein binding; glycosaminoglycan binding; fibroblast growth factor binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding

Biological Process: transforming growth factor beta receptor complex assembly; blood vessel development; blastocyst development; in utero embryonic development; positive regulation of transforming growth factor beta receptor signaling pathway; cardiac muscle cell proliferation; negative regulation of cell motility; palate development; liver development; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; BMP signaling pathway; embryonic development; regulation of protein binding; transforming growth factor beta receptor signaling pathway; epithelial to mesenchymal transition; ventricular cardiac muscle morphogenesis; immune response; protein complex assembly; cell growth; negative regulation of transforming growth factor beta receptor signaling pathway; regulation of blood vessel size; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation