SLC36A1 sirna

SLC36A1 siRNA (Mouse)

Cat. Num. AAA8240464

• Gene Names: Slc36a1; Pat1; AI839897; 5830411H19Rik
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: SLC36A1; SLC36A1 siRNA (Mouse); PAT1; Proton-coupled amino acid transporter 1; Proton/amino acid transporter 1; Solute carrier family 36 member 1; SLC36A1 sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: SLC36A1 siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 475

• Applicable Applications for SLC36A1 sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse SLC36A1 gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for SLC36A1 sirna

siRNA to inhibit SLC36A1 expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 145207965
• NCBI GeneID: 215335
• NCBI Accession #: NP_694779.3
• NCBI GenBank Nucleotide #: NM_153139.4
• UniProt Accession #: Q8K4D3; Q811N9
• Molecular Weight: 52,466 Da
• NCBI Official Full Name: proton-coupled amino acid transporter 1
• NCBI Official Synonym Full Names: solute carrier family 36 (proton/amino acid symporter), member 1
• NCBI Official Symbol: Slc36a1
• NCBI Official Synonym Symbols: Pat1; AI839897; 5830411H19Rik
• NCBI Protein Information: proton-coupled amino acid transporter 1
• UniProt Protein Name: Proton-coupled amino acid transporter 1
• Protein Family: Proton-coupled amino acid transporter
• UniProt Gene Name: Slc36a1
• UniProt Synonym Gene Names: Pat1; Proton/amino acid transporter 1
• UniProt Entry Name: S36A1_MOUSE

Uniprot Description

SLC36A1: Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid. Belongs to the amino acid/polyamine transporter 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, SLC family

Cellular Component: membrane; lysosome; lysosomal membrane; endoplasmic reticulum; vacuolar membrane; plasma membrane; integral to membrane

Molecular Function: glycine transmembrane transporter activity; neutral amino acid transmembrane transporter activity; symporter activity; L-proline transmembrane transporter activity; hydrogen:amino acid symporter activity; hydrogen ion transmembrane transporter activity; L-alanine transmembrane transporter activity; L-tyrosine transmembrane transporter activity

Biological Process: glycine transport; neutral amino acid transport; proton transport; transport; amino acid transport; proline transport; L-alanine transport