RAET1B sirna

RAET1B siRNA (Mouse)

Cat. Num. AAA8218586

• Gene Names: Raet1b; RAE-1beta
• Reactivity: Mouse
• Applications: RNA Interference (RNAi)
• Purity: > 97%
• Synonyms: RAET1B; RAET1B siRNA (Mouse); Retinoic acid early-inducible protein 1-beta; RAE-1-beta; RAET1B sirna

• Host: Synthetic
• Reactivity: Mouse
• Specificity: RAET1B siRNA (Mouse) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
• Purity/Purification: > 97%
• Form/Format: Lyophilized powder
• Sequence Length: 253

• Applicable Applications for RAET1B sirna: RNA Interference (RNAi)
• Quality Control: Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
• Directions for Use: We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
• Components: We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of mouse RAET1B gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
• Preparation and Storage: Shipped at 4 degree C. Store at -20 degree C for one year.

Related Product Information for RAET1B sirna

siRNA to inhibit RAET1B expression using RNA interference

NCBI and Uniprot Product Information

• NCBI GI #: 6679619
• NCBI GeneID: 19369
• NCBI Accession #: NP_033043.1
• NCBI GenBank Nucleotide #: NM_009017.1
• UniProt Accession #: O08603; A2RS95
• Molecular Weight: 28,625 Da
• NCBI Official Full Name: retinoic acid early-inducible protein 1-beta
• NCBI Official Synonym Full Names: retinoic acid early transcript beta
• NCBI Official Symbol: Raet1b
• NCBI Official Synonym Symbols: RAE-1beta
• NCBI Protein Information: retinoic acid early-inducible protein 1-beta
• UniProt Protein Name: Retinoic acid early-inducible protein 1-beta
• Protein Family: Retinoic acid early-inducible protein
• UniProt Gene Name: Raet1b
• UniProt Synonym Gene Names: RAE-1-beta
• UniProt Entry Name: RAE1B_MOUSE

Uniprot Description

Raet1b: Acts as a ligand for NKG2D. Belongs to the NKG2D ligand family.

Cellular Component: anchored to external side of plasma membrane; anchored to plasma membrane; membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; positive regulation of interferon-gamma production; positive regulation of nitric oxide biosynthetic process; defense response to bacterium; immune response; positive regulation of immune response to tumor cell; susceptibility to natural killer cell mediated cytotoxicity; positive regulation of natural killer cell activation; positive regulation of macrophage activation